FRAT2 (FRAT regulator of WNT signaling pathway 2)

2003-02-01  

Identity

HGNC
FRAT2
LOCATION
10q24.1
LOCUSID
23401
ALIAS
FRAT-2

Other Information

Locus ID:

NCBI: 23401
MIM: 605006
HGNC: 16048
Ensembl: ENSG00000181274

Variants:

dbSNP: 23401
ClinVar: 23401
TCGA: ENSG00000181274
COSMIC: FRAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181274ENST00000371019O75474

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Beta-catenin phosphorylation cascadeREACTOMER-HSA-196299
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
361533702022The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.6
361533702022The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.6
206136732010Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.8
206136732010Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.8
174335042008Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.27
174335042008Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.27
155228772005FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.6
155228772005FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.6

Citation

Dessen P

FRAT2 (FRAT regulator of WNT signaling pathway 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/465/frat2-(frat-regulator-of-wnt-signaling-pathway-2)