S1PR5 (sphingosine-1-phosphate receptor 5)

2007-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
EDG8,Edg-8,S1P5,SPPR-1,SPPR-2
FUSION GENES

Other Information

Locus ID:

NCBI: 53637
MIM: 605146
HGNC: 14299
Ensembl: ENSG00000180739

Variants:

dbSNP: 53637
ClinVar: 53637
TCGA: ENSG00000180739
COSMIC: S1PR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180739ENST00000333430Q9H228
ENSG00000180739ENST00000439028Q9H228
ENSG00000180739ENST00000590601K7EIT5
ENSG00000180739ENST00000617721A0A087WXR8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342714372021Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.4
342714372021Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.4
292484942018S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.26
292484942018S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.26
278683022017Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.20
283519532017Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression.20
278683022017Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.20
283519532017Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression.20
256015192015Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.9
256015192015Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.9
235511782014Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions.24
249033842014The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.26
235511782014Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions.24
249033842014The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.26
225411102012[Influence of NK cell S1PR5 expression on graft versus host disease in allogeneic hematopoietic stem cell transplantation].0

Citation

Dessen P

S1PR5 (sphingosine-1-phosphate receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46503/s1pr5-(sphingosine-1-phosphate-receptor-5)