GRM4 (glutamate metabotropic receptor 4)

2007-02-01  

Identity

HGNC
GRM4
LOCATION
6p21.31
LOCUSID
2914
ALIAS
GPRC1D,MGLUR4,mGlu4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2914
MIM: 604100
HGNC: 4596
Ensembl: ENSG00000124493

Variants:

dbSNP: 2914
ClinVar: 2914
TCGA: ENSG00000124493
COSMIC: GRM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124493ENST00000374177Q14833
ENSG00000124493ENST00000374181B7ZLU9
ENSG00000124493ENST00000455714Q14833
ENSG00000124493ENST00000535756Q14833
ENSG00000124493ENST00000538487Q14833
ENSG00000124493ENST00000538487A1L4F9
ENSG00000124493ENST00000544773Q14833
ENSG00000124493ENST00000609222Q14833
ENSG00000124493ENST00000609278V9GYR3
ENSG00000124493ENST00000609443V9GYB0

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
330688162021Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.6
341355102021Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4.52
342444592021Regulation and functional consequences of mGlu(4) RNA editing.2
330688162021Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.6
341355102021Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4.52
342444592021Regulation and functional consequences of mGlu(4) RNA editing.2
315818812020GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4.6
315818812020GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4.6
309543582019The developmental expression of metabotropic glutamate receptor 4 in prenatal human frontal lobe and neurogenesis regions.1
314921162019Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p.18
315271312019Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23.20
309543582019The developmental expression of metabotropic glutamate receptor 4 in prenatal human frontal lobe and neurogenesis regions.1
314921162019Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p.18
315271312019Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23.20
293397162018To Explore the Mechanism of the GRM4 Gene in Osteosarcoma by RNA Sequencing and Bioinformatics Approach.5

Citation

Dessen P

GRM4 (glutamate metabotropic receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46524/grm4-(glutamate-metabotropic-receptor-4)