Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
SIR2,SIR2L,SIR2L2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22933
MIM: 604480
HGNC: 10886
Ensembl: ENSG00000068903
Variants:
dbSNP: 22933
ClinVar: 22933
TCGA: ENSG00000068903
COSMIC: SIRT2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131301952 | gefitinib | Chemical | ClinicalAnnotation | associated | PD | 31664190 | |
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation | associated | PD | 31664190 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37625115 | 2024 | Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma. | 2 |
| 38216561 | 2024 | FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation. | 2 |
| 38287804 | 2024 | KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2. | 0 |
| 38360128 | 2024 | Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice. | 0 |
| 38554113 | 2024 | SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner. | 0 |
| 38647411 | 2024 | Biophysical insights into the dimer formation of human Sirtuin 2. | 1 |
| 37625115 | 2024 | Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma. | 2 |
| 38216561 | 2024 | FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation. | 2 |
| 38287804 | 2024 | KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2. | 0 |
| 38360128 | 2024 | Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice. | 0 |
| 38554113 | 2024 | SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner. | 0 |
| 38647411 | 2024 | Biophysical insights into the dimer formation of human Sirtuin 2. | 1 |
| 36082450 | 2023 | SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer. | 1 |
| 36453571 | 2023 | Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation. | 3 |
| 36474029 | 2023 | A novel circ_0018553 protects against angiotensin-induced cardiac hypertrophy in cardiomyocytes by modulating the miR-4731/SIRT2 signaling pathway. | 4 |
Citation
Dessen P
SIRT2 (sirtuin 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46529/sirt2-(sirtuin-2)
