SLC29A1 (solute carrier family 29 member 1 (Augustine blood group))

2007-02-01  

Identity

HGNC
SLC29A1
LOCATION
6p21.1
LOCUSID
2030
ALIAS
ENT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2030
MIM: 602193
HGNC: 11003
Ensembl: ENSG00000112759

Variants:

dbSNP: 2030
ClinVar: 2030
TCGA: ENSG00000112759
COSMIC: SLC29A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112759ENST00000371708Q99808
ENSG00000112759ENST00000371713Q99808
ENSG00000112759ENST00000371724Q99808
ENSG00000112759ENST00000371731A0A2U3TZM6
ENSG00000112759ENST00000371740A0A2U3TZJ7
ENSG00000112759ENST00000371755Q99808
ENSG00000112759ENST00000393841A0A2U3TZM5
ENSG00000112759ENST00000393844Q99808
ENSG00000112759ENST00000642777A0A2R8YEH8
ENSG00000112759ENST00000643028A0A2R8Y6D1
ENSG00000112759ENST00000643869A0A2R8Y567
ENSG00000112759ENST00000645692A0A2R8Y801
ENSG00000112759ENST00000646251A0A2R8YFB9
ENSG00000112759ENST00000646582A0A2R8Y854
ENSG00000112759ENST00000647460A0A2R8YFI6
ENSG00000112759ENST00000651428Q99808
ENSG00000112759ENST00000652453Q99808
ENSG00000112759ENST00000652680Q99808

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneREACTOMER-HSA-83936

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD20812847
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD20812847
PA166171170tipiracil hydrochlorideChemicalClinicalAnnotationassociatedPD28992563
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD24361227
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD20665488, 24361227
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD20665488
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD28992563
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD20812847
PA449748gemcitabineChemicalClinicalAnnotation, Literature, MultilinkAnnotation, PathwayassociatedPD20665488, 22705007, 24361227, 24475233, 25162786
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD24361227
PA451241ribavirinChemicalClinicalAnnotationassociatedPD20812847
PA451775trifluridineChemicalClinicalAnnotationassociatedPD28992563

References

Pubmed IDYearTitleCitations
382727172024The prognostic and predictive role of class III β-Tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinoma.0
382727172024The prognostic and predictive role of class III β-Tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinoma.0
364642472023Erythrocyte type 1 equilibrative nucleoside transporter expression in sickle cell disease and sickle cell trait.0
368349622023Solute Carrier Family 29A1 Mediates In Vitro Resistance to Azacitidine in Acute Myeloid Leukemia Cell Lines.0
377254372023Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.3
364642472023Erythrocyte type 1 equilibrative nucleoside transporter expression in sickle cell disease and sickle cell trait.0
368349622023Solute Carrier Family 29A1 Mediates In Vitro Resistance to Azacitidine in Acute Myeloid Leukemia Cell Lines.0
377254372023Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.3
330524302021Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers.2
336908422021The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.12
343315612021Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.3
345039742021Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.22
330524302021Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers.2
336908422021The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.12
343315612021Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.3

Citation

Dessen P

SLC29A1 (solute carrier family 29 member 1 (Augustine blood group))

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46530/slc29a1-(solute-carrier-family-29-member-1-(augustine-blood-group))