NCL (nucleolin)

2007-02-01  

Identity

HGNC
NCL
LOCATION
2q37.1
LOCUSID
4691
ALIAS
C23,Nsr1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4691
MIM: 164035
HGNC: 7667
Ensembl: ENSG00000115053

Variants:

dbSNP: 4691
ClinVar: 4691
TCGA: ENSG00000115053
COSMIC: NCL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115053ENST00000322723P19338
ENSG00000115053ENST00000322723A0A024R4A0
ENSG00000115053ENST00000356936H7BY16
ENSG00000115053ENST00000417652C9J1H7
ENSG00000115053ENST00000436894C9JYW2
ENSG00000115053ENST00000453992C9JLB1
ENSG00000115053ENST00000454824C9JWL1

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pathogenic Escherichia coli infectionKEGGko05130
Pathogenic Escherichia coli infectionKEGGhsa05130

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384091362024RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.0
385580982024TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.0
384091362024RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.0
385580982024TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.0
381392942023Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models.1
381392942023Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models.1
351288352022Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.3
355628812022Overexpression of Nucleolin and Associated Genes in Prostate Cancer.1
361077692022The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA.0
362095212022Nucleolin expression has prognostic value in neuroblastoma patients.4
363356472022Nucleolin; A tumor associated antigen as a potential lung cancer biomarker.0
351288352022Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.3
355628812022Overexpression of Nucleolin and Associated Genes in Prostate Cancer.1
361077692022The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA.0
362095212022Nucleolin expression has prognostic value in neuroblastoma patients.4

Citation

Dessen P

NCL (nucleolin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46574/ncl-(nucleolin)