Identity
HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
11-DH,11-beta-HSD1,CORTRD2,HDL,HSD11,HSD11B,HSD11L,SDR26C1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3290
MIM: 600713
HGNC: 5208
Ensembl: ENSG00000117594
Variants:
dbSNP: 3290
ClinVar: 3290
TCGA: ENSG00000117594
COSMIC: HSD11B1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | 25587129 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK | 25587129 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37280272 | 2023 | Hyperglycemia-activated 11β-hydroxysteroid dehydrogenase type 1 increases endoplasmic reticulum stress and skin barrier dysfunction. | 1 |
| 37855366 | 2023 | G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity. | 1 |
| 37943405 | 2023 | 11-beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene expression in muscle is linked to reduced skeletal muscle index in sarcopenic patients. | 0 |
| 37280272 | 2023 | Hyperglycemia-activated 11β-hydroxysteroid dehydrogenase type 1 increases endoplasmic reticulum stress and skin barrier dysfunction. | 1 |
| 37855366 | 2023 | G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity. | 1 |
| 37943405 | 2023 | 11-beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene expression in muscle is linked to reduced skeletal muscle index in sarcopenic patients. | 0 |
| 36446766 | 2022 | Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH. | 4 |
| 36446766 | 2022 | Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH. | 4 |
| 32360870 | 2021 | Lack of association of the 11 beta-hydroxysteroid dehydrogenase type 1 gene 25669dupA polymorphism with obesity and metabolic syndrome. | 0 |
| 32453474 | 2021 | Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes. | 3 |
| 32880710 | 2021 | Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity. | 1 |
| 33639236 | 2021 | The rise in expression and activity of 11β-HSD1 in human mesenchymal progenitor cells induces adipogenesis through increased local cortisol synthesis. | 4 |
| 33722534 | 2021 | Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model. | 6 |
| 34072239 | 2021 | Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin. | 5 |
| 34639470 | 2021 | Association between Selected Polymorphisms rs12086634, rs846910, rs4844880, rs3753519 of 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) and the Presence of Insulin Resistance in the Polish Population of People Living in Upper Silesia. | 0 |
Citation
Dessen P
HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46584/hsd11b1-(hydroxysteroid-11-beta-dehydrogenase-1)
