TXNRD1 (thioredoxin reductase 1)

2007-02-01  

Identity

HGNC
TXNRD1
LOCATION
12q23.3
LOCUSID
7296
ALIAS
GRIM-12,TR,TR1,TRXR1,TXNR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7296
MIM: 601112
HGNC: 12437
Ensembl: ENSG00000198431

Variants:

dbSNP: 7296
ClinVar: 7296
TCGA: ENSG00000198431
COSMIC: TXNRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198431ENST00000354940F8W809
ENSG00000198431ENST00000388854A0A087WSW9
ENSG00000198431ENST00000397736E2QRB9
ENSG00000198431ENST00000429002A0A087WSY9
ENSG00000198431ENST00000503506Q16881
ENSG00000198431ENST00000524698Q16881
ENSG00000198431ENST00000525566Q16881
ENSG00000198431ENST00000526266E9PLT3
ENSG00000198431ENST00000526390Q16881
ENSG00000198431ENST00000526580A0A0B4J225
ENSG00000198431ENST00000526691Q16881
ENSG00000198431ENST00000526950A0A182DWI3
ENSG00000198431ENST00000527335E9PKD3
ENSG00000198431ENST00000527688E9PIR7
ENSG00000198431ENST00000528079E9PJU2
ENSG00000198431ENST00000529546Q16881
ENSG00000198431ENST00000529751E9PRI8
ENSG00000198431ENST00000529784E9PQI3
ENSG00000198431ENST00000531689E9PKI4
ENSG00000198431ENST00000531691E9PIZ5

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Selenocompound metabolismKEGGko00450
Pyrimidine metabolismKEGGhsa00240
Selenocompound metabolismKEGGhsa00450
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of diphtheria toxinREACTOMER-HSA-5336415
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested MeSeO2H into MeSeHREACTOMER-HSA-5263617
Metabolism of ingested H2SeO4 and H2SeO3 into H2SeREACTOMER-HSA-2408550

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA37091TXNGenePathwayassociated23913015
PA451898vitamin cChemicalPathwayassociated23913015

References

Pubmed IDYearTitleCitations
381536962024LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1.0
382430442024PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway.0
382779632024Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.0
385650592024Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.0
386367902024Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.0
381536962024LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1.0
382430442024PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway.0
382779632024Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.0
385650592024Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.0
386367902024Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.0
350667512023Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells.7
365608812023Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma.4
365772502023Inhibition of thioredoxin reductase activity reduces the antioxidant defense capacity of human pluripotent stem cells under conditions of mild but not severe oxidative stress.2
366334842023Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.3
367541522023TXNRD1 knockdown inhibits the proliferation of endothelial cells subjected to oscillatory shear stress via activation of the endothelial nitric oxide synthase/apoptosis pathway.1

Citation

Dessen P

TXNRD1 (thioredoxin reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46587/txnrd1-(thioredoxin-reductase-1)