HMGN1 (high mobility group nucleosome binding domain 1)

2007-02-01  

Identity

HGNC
LOCATION
21q22.2
LOCUSID
ALIAS
HMG14
FUSION GENES

Other Information

Locus ID:

NCBI: 3150
MIM: 163920
HGNC: 4984
Ensembl: ENSG00000205581

Variants:

dbSNP: 3150
ClinVar: 3150
TCGA: ENSG00000205581
COSMIC: HMGN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205581ENST00000288344H7BXJ5
ENSG00000205581ENST00000380747A6NEL0
ENSG00000205581ENST00000380748A6NL93
ENSG00000205581ENST00000380749P05114
ENSG00000205581ENST00000419378F2Z2Y5
ENSG00000205581ENST00000431390F2Z2Y5
ENSG00000205581ENST00000436324F2Z2W6
ENSG00000205581ENST00000443046F2Z2W6
ENSG00000205581ENST00000652622A0A494C035

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221846352012High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.48
160616522005Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.47
195245412009HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.33
211731662011Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.29
220097412011The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.23
182875272008Cell cycle-dependent binding of HMGN proteins to chromatin.20
179382092007HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.13
162539892005Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling.11
223932582012The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.10
271000872016Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.9

Citation

Dessen P

HMGN1 (high mobility group nucleosome binding domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46588/hmgn1-(high-mobility-group-nucleosome-binding-domain-1)