Identity
HGNC
LOCATION
6p12.1
LOCUSID
ALIAS
GCL,GCS,GLCL,GLCLC
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2729
MIM: 606857
HGNC: 4311
Ensembl: ENSG00000001084
Variants:
dbSNP: 2729
ClinVar: 2729
TCGA: ENSG00000001084
COSMIC: GCLC
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 22824134 | |
| PA451544 | sulfamethoxazole | Chemical | ClinicalAnnotation | associated | PD | 22824134 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35241341 | 2023 | Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma. | 3 |
| 37146698 | 2023 | H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells. | 6 |
| 38049865 | 2023 | SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation. | 1 |
| 35241341 | 2023 | Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma. | 3 |
| 37146698 | 2023 | H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells. | 6 |
| 38049865 | 2023 | SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation. | 1 |
| 34642912 | 2022 | Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women. | 3 |
| 35386070 | 2022 | Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study. | 3 |
| 36359768 | 2022 | Ferroptosis-Related Gene GCLC Is a Novel Prognostic Molecular and Correlates with Immune Infiltrates in Lung Adenocarcinoma. | 5 |
| 34642912 | 2022 | Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women. | 3 |
| 35386070 | 2022 | Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study. | 3 |
| 36359768 | 2022 | Ferroptosis-Related Gene GCLC Is a Novel Prognostic Molecular and Correlates with Immune Infiltrates in Lung Adenocarcinoma. | 5 |
| 33357455 | 2021 | Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. | 117 |
| 33357455 | 2021 | Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. | 117 |
| 32054366 | 2020 | Genetic susceptibility analysis of GCLC rs17883901 polymorphism to preeclampsia in Chinese Han women. | 1 |
Citation
Dessen P
GCLC (glutamate-cysteine ligase catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46590/gclc-(glutamate-cysteine-ligase-catalytic-subunit)
