KLHL2 (kelch like family member 2)

2007-02-01  

Identity

HGNC
KLHL2
LOCATION
4q32.3
LOCUSID
11275
ALIAS
ABP-KELCH,MAV,MAYVEN

Other Information

Locus ID:

NCBI: 11275
MIM: 605774
HGNC: 6353
Ensembl: ENSG00000109466

Variants:

dbSNP: 11275
ClinVar: 11275
TCGA: ENSG00000109466
COSMIC: KLHL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109466ENST00000226725O95198
ENSG00000109466ENST00000421009E9PEX9
ENSG00000109466ENST00000506761B4DFZ5
ENSG00000109466ENST00000506824D6RAP5
ENSG00000109466ENST00000509704D6RGC3
ENSG00000109466ENST00000511305D6R9G5
ENSG00000109466ENST00000514860O95198
ENSG00000109466ENST00000538127O95198

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
238382902013KLHL2 interacts with and ubiquitinates WNK kinases.20
238382902013KLHL2 interacts with and ubiquitinates WNK kinases.20
215498402011Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.12
215498402011Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.12
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
157357242005Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.4
157357242005Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.4

Citation

Dessen P

KLHL2 (kelch like family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46593/klhl2-(kelch-like-family-member-2)