HLA-B (major histocompatibility complex, class I, B)

2007-02-01 Affiliation

Identity

HGNC

HLA-B

LOCATION

6p21.33

LOCUSID

3106

ALIAS

AS,B-4901,HLAB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3106
MIM: 142830
HGNC: 4932
Ensembl: ENSG00000234745

Variants:

dbSNP: 3106
ClinVar: 3106
TCGA: ENSG00000234745
COSMIC: HLA-B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000234745	ENST00000412585	P01889
ENSG00000234745	ENST00000412585	E5FQ95
ENSG00000234745	ENST00000434333	F6U0H7
ENSG00000234745	ENST00000639848	A0A1W2PPR8
ENSG00000234745	ENST00000640094	A0A1W2PP29
ENSG00000234745	ENST00000640615	A0A1W2PQE2

Expression (GTEx)

1000

2000

3000

4000

5000

6000

7000

8000

9000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Antigen processing and presentation	KEGG	ko04612
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Type I diabetes mellitus	KEGG	ko04940
Autoimmune thyroid disease	KEGG	ko05320
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Antigen processing and presentation	KEGG	hsa04612
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Type I diabetes mellitus	KEGG	hsa04940
Autoimmune thyroid disease	KEGG	hsa05320
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Viral myocarditis	KEGG	hsa05416
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	REACTOME	R-HSA-983170
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Endosomal/Vacuolar pathway	REACTOME	R-HSA-1236977
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Interferon gamma signaling	REACTOME	R-HSA-877300
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10715	sulfamethoxazole / trimethoprim	Chemical	VariantAnnotation	associated	PD	26086150
PA143485705	antiepileptics	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	17509004, 23692434, 25647819
PA162263525	neuropathic pain	Disease	VariantAnnotation	associated	PD	21676164
PA162316739	Maculopapular Exanthema	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	21790926, 22818943, 22909208, 18637831, 20833111, 21071176, 21169036, 21306565, 21397523, 22429379, 22818943, 23830818, 24897291, 25327504, 25495410, 26996548, 27666425, 29512326
PA164712499	Antithyroid Preparations	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	27157822
PA164742970	carbimazole	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	26151496, 26599303
PA164742987	clavulanate	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	30664875
PA164746820	fosphenytoin	Chemical	LabelAnnotation	associated
PA164749390	peginterferon alfa-2a	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	23360626
PA164779048	interferon alfa-2a, recombinant	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	12873589
PA164781042	flucloxacillin	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PD	18637831, 19483685, 19696695, 23032409, 23132554, 23291545, 23596311, 24731753, 18256392, 19483685, 30664875
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	23360626
PA164925725	Toxic liver disease	Disease	VariantAnnotation	associated	PD	17339877, 25714001, 26546620
PA165291492	pazopanib	Chemical	LabelAnnotation, VariantAnnotation	associated	PD	26546620
PA165954643	HLA-B*13:01:01	Haplotype	VipGene	associated
PA165954769	HLA-B*15:02:01	Haplotype	LabelAnnotation, VipGene	associated		14659971, 15024534, 15057820, 16415921, 16538176, 16981842, 17896897, 18256392, 18636788, 18637831, 19018717, 19029983, 19109108, 19696695, 19915237, 20001755, 20235791, 20345939, 20390258, 20536296, 20637045, 20833111, 21068649, 21071176, 21149285, 21169036, 21204807, 21216202, 21244392, 21306565, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22322005, 22348435, 22722860, 22818943, 22909208, 23132554, 23159358, 23551241, 23692434, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24597466, 24897291, 25096692, 7794310, 9333104, 10629466
PA165955111	HLA-B*27:01	Haplotype	VipGene	associated		22513152, 24504800, 16777585
PA165955112	HLA-B*27:02:01	Haplotype	VipGene	associated		17448825, 22513152, 24504800, 16777585
PA165955115	HLA-B*27:04:01	Haplotype	VipGene	associated		17448825, 22513152, 24504800, 16777585
PA165955118	HLA-B*27:05:02	Haplotype	VipGene	associated		17448825, 22513152, 24504800, 16777585
PA165955135	HLA-B*27:07:01	Haplotype	VipGene	associated		17448825, 22513152, 24504800, 16777585
PA165955262	HLA-B*35:05:01	Haplotype	VipGene	associated		19104471
PA165956565	HLA-B*57:01:01	Haplotype	LabelAnnotation, VipGene	associated		11888582, 11943262, 12409746, 14685052, 15016610, 15247625, 16609367, 16758424, 17075282, 17356469, 17545699, 18018760, 18025891, 18256392, 18444831, 18479171, 18637831, 18684101, 19483685, 19696695, 20534626, 21091860, 21106806, 21412232, 21501118, 21510768, 22197535, 22304574, 22651253, 22722860, 22913531, 23032409, 23132554, 23280011, 23291545, 23596311, 24731753, 10449301
PA165956579	HLA-B*57:03:01	Haplotype	VipGene	associated		21106806, 14685052
PA165956674	HLA-B*59:01:01:01	Haplotype	VipGene	associated		21342230, 9109770, 20504258
PA165987830	HLA-B*57:01	Haplotype	GuidelineAnnotation, LabelAnnotation	associated
PA165987831	HLA-B*58:01	Haplotype	LabelAnnotation, VipGene	associated		17075282, 18018760, 18192896, 18256392, 18637831, 18684101, 19018717, 19696695, 20534626, 20536296, 21301380, 21393610, 21501118, 21510768, 21545408, 21790926, 21912425, 22304574, 22348415, 22651253, 22909208, 22913531, 23132554, 23280011, 23381951, 23600531, 23669020, 24591375, 7794310, 16609367
PA166048807	Behcet Syndrome	Disease	VipGene	associated
PA166048814	Hyperuricemia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	17587850, 18192896, 19002350, 19018717, 19483528, 19696695, 21301380, 21393610, 21545408, 21790926, 21912425, 22017528, 22348415, 22901319, 22909208, 23280169, 23600531, 23669020, 24152157, 24858023, 25115449, 25257159, 25327504, 25566896, 25899558, 26104483, 26655481, 26937673, 26996548, 28509689, 28857441, 30383575, 32433341
PA166048850	Soft Tissue Neoplasms	Disease	VariantAnnotation	associated	PD	26546620
PA166115521	trichloroethylene	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD
PA166115842	UGT1A1*28	Haplotype	LabelAnnotation	associated
PA166119041	drug-induced liver injury	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD	23032409, 23291545, 23596311, 24731753, 19483685, 30664875
PA166120926	dress syndrome	Disease	VariantAnnotation	associated	PD
PA166120927	drug reaction with eosinophilia and systemic symptoms	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	19002350, 19104471, 20235791, 22901319, 23025739, 24225276, 24322785, 25096692, 25303297, 26927288, 26928377, 26937673, 28391407, 28819312, 28885988, 29458119
PA166120928	erythema exudativum multiforme	Disease	VariantAnnotation, VipGene	ambiguous	PD	23669020
PA166120929	severe cutaneous adverse reactions	Disease	ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	16415921, 16538176, 16981842, 18192896, 18256392, 18637831, 19018717, 19483528, 19696695, 19915237, 20345939, 20504258, 20833111, 21204807, 21244392, 21342230, 21397523, 21424386, 21676164, 21912425, 21917426, 22053601, 22348435, 22901319, 23132554, 23280169, 23669020, 23692434, 24225276, 24268988, 24322785, 24394201, 24399721, 9109770, 15057820, 16981842, 19002350, 19668019, 20345939, 20504258, 20833111, 21071176, 21204807, 21244392, 21301380, 21306565, 21393610, 21397523, 21424386, 21676164, 21912425, 21917426, 22258364, 22348415, 22348435, 22909208, 23551241, 23600531, 23604100, 23884208, 24152261, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 25096692, 25115449, 25257159, 25495410, 25657656, 25714001, 26104483, 26996548, 28885988, 29458119, 29512326, 29629814
PA166123368	schizoaffective disorder	Disease	VariantAnnotation	associated	PD	2222133
PA166152644	schizencephaly	Disease	VariantAnnotation	associated	PD	27020614
PA166184501	lamivudine / abacavir	Chemical	LabelAnnotation	associated
PA166184503	zidovudine / lamivudine / abacavir	Chemical	LabelAnnotation	associated
PA166184505	dolutegravir / abacavir / lamivudine	Chemical	LabelAnnotation	associated
PA443297	Agranulocytosis	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	2222133, 26599303, 26876947, 27157822, 9587740
PA443624	Carcinoma, Renal Cell	Disease	VariantAnnotation	associated	PD	26546620
PA443876	Dermatitis, Exfoliative	Disease	VariantAnnotation	associated	PD	25566896
PA443936	Drug Hypersensitivity	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	11943262, 15016610, 15247625, 18444831, 21091860, 22197535, 11888582, 15024131, 15247625, 16868443, 16981842, 17587850, 18184080, 18192896, 18256392, 19002350, 19018717, 19104471, 19195327, 19483528, 19696695, 21091860, 21301380, 21393610, 21505298, 21545408, 21790926, 21912425, 21917426, 22017528, 22197535, 22211527, 22258364, 22348415, 22429379, 22901319, 22909208, 23280169, 23600531, 23604100, 23669020, 24152157, 24152261, 24268988, 24858023, 24911354, 25115449, 25257159, 25327504, 25361850, 25566896, 25714001, 25877443, 25899558, 25934581, 26104483, 26655481, 26937673, 26996548, 27403179, 27530904, 28509689, 28857441, 28885988, 29458119, 29512326, 30383575, 32433341
PA443937	Drug Toxicity	Disease	VariantAnnotation	associated	PD	22211527, 27527109
PA444059	Epidermal Necrolysis, Toxic	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	14659971, 15024534, 15057820, 16538176, 16981842, 17896897, 18256392, 18636788, 18637831, 19018717, 19029983, 19109108, 19696695, 19915237, 20001755, 20235791, 20345939, 20390258, 20536296, 20637045, 20833111, 21068649, 21071176, 21149285, 21169036, 21204807, 21216202, 21244392, 21306565, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22322005, 22348435, 22722860, 22818943, 22909208, 23132554, 23159358, 23551241, 23692434, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24597466, 24897291, 25096692, 7794310, 9333104, 10629466, 15057820, 16415921, 16538176, 16981842, 17509004, 17587850, 18192896, 18637831, 19002350, 19018717, 19104471, 19483528, 19696695, 19915237, 20235791, 20345939, 20504258, 20833111, 21216202, 21244392, 21301380, 21334226, 21393610, 21397523, 21424386, 21428768, 21545408, 21676164, 21790926, 21912425, 21917426, 22017528, 22053601, 22348415, 22348435, 22429379, 22500513, 22901319, 22909208, 23132554, 23280169, 23551241, 23600531, 23669020, 23692434, 23712814, 23884208, 24152157, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24858023, 24897291, 25096692, 25115449, 25257159, 25266342, 25305458, 25327504, 25355835, 25428396, 25566896, 25647819, 25899558, 25918017, 25970075, 26086150, 26104483, 26319500, 26655481, 26927288, 26928377, 26937673, 26996548, 27020614, 27096699, 27888155, 28391407, 28509689, 28570299, 28819312, 28857441, 29076187, 30242287, 30383575, 32433341, 9109770
PA444065	Epilepsy	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	15057820, 17509004, 18637831, 19694795, 20235791, 21071176, 21169036, 21216202, 21306565, 21334226, 22053601, 22258364, 22818943, 23692434, 23712814, 24399721, 24496695, 24897291, 25428396, 25647819, 27096699, 27666425
PA444109	Exanthema	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	19104471, 21393610, 22053601, 27096699
PA444281	Glaucoma	Disease	VariantAnnotation	associated	PD	25970075, 9109770
PA444318	Gout	Disease	VariantAnnotation	associated	PD	23280169
PA444329	Graves Disease	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	26151496, 26599303
PA444445	Hepatitis C	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD	12873589, 23360626
PA444546	Hypersensitivity	Disease	MultilinkAnnotation, VariantAnnotation	ambiguous	PD	26230858
PA444684	Kidney Failure, Chronic	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	17587850, 18192896, 19002350, 19018717, 19483528, 19696695, 21301380, 21393610, 21545408, 21790926, 21912425, 22017528, 22348415, 22901319, 22909208, 23280169, 23600531, 23669020, 24152157, 24858023, 25115449, 25257159, 25327504, 25566896, 25899558, 26104483, 26655481, 26937673, 26996548, 28509689, 28857441, 30383575, 32433341
PA444745	Leprosy	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	23604100, 24152261, 28885988, 29458119, 29512326
PA444859	Malaria	Disease	VipGene	associated
PA444987	Multiple Sclerosis	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	27020477
PA445204	Ovarian Neoplasms	Disease	VariantAnnotation	associated	PD	26546620
PA445594	Sarcoma	Disease	VariantAnnotation	associated	PD	26546620
PA445629	Seizures	Disease	VariantAnnotation	associated	PD	18785891, 19321411, 22429379
PA445676	Skin Diseases	Disease	VariantAnnotation	associated	PD	29458119
PA445724	Spondylitis, Ankylosing	Disease	VipGene	associated		17448825, 22513152, 24504800, 16777585
PA445738	Stevens-Johnson Syndrome	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	14659971, 15024534, 15057820, 16538176, 16981842, 17896897, 18256392, 18636788, 18637831, 19018717, 19029983, 19109108, 19696695, 19915237, 20001755, 20235791, 20345939, 20390258, 20536296, 20637045, 20833111, 21068649, 21071176, 21149285, 21169036, 21204807, 21216202, 21244392, 21306565, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22322005, 22348435, 22722860, 22818943, 22909208, 23132554, 23159358, 23551241, 23692434, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24597466, 24897291, 25096692, 7794310, 9333104, 10629466, 15057820, 16415921, 16538176, 16981842, 17509004, 17587850, 18192896, 18637831, 18785891, 19002350, 19018717, 19104471, 19321411, 19483528, 19694795, 19696695, 19915237, 20235791, 20345939, 20504258, 20833111, 21216202, 21244392, 21301380, 21334226, 21342230, 21393610, 21397523, 21424386, 21428768, 21545408, 21676164, 21790926, 21912425, 21917426, 22013310, 22017528, 22053601, 22348415, 22348435, 22429379, 22500513, 22901319, 22909208, 23132554, 23280169, 23551241, 23600531, 23669020, 23692434, 23712814, 23884208, 24152157, 24225276, 24236482, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24858023, 24897291, 25096692, 25115449, 25257159, 25266342, 25305458, 25327504, 25355835, 25428396, 25495410, 25566896, 25647819, 25899558, 25918017, 25970075, 26086150, 26104483, 26319500, 26655481, 26927288, 26928377, 26937673, 26996548, 27020614, 27096699, 27888155, 28391407, 28509689, 28570299, 28819312, 28857441, 28885988, 29076187, 30242287, 30383575, 32433341, 9109770
PA446114	Arthritis, Gouty	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	17587850, 18192896, 19002350, 19018717, 19483528, 19696695, 21301380, 21393610, 21545408, 21790926, 21912425, 22017528, 22348415, 22901319, 22909208, 23280169, 23600531, 23669020, 24152157, 24858023, 25115449, 25257159, 25327504, 25566896, 25899558, 26104483, 26655481, 26937673, 26996548, 28509689, 28857441, 30383575, 32433341
PA446827	Hematologic Neoplasms	Disease	VariantAnnotation	ambiguous	PD	24858023
PA447199	Bipolar Disorder	Disease	VariantAnnotation	associated	PD	27096699
PA447216	Schizophrenia	Disease	VariantAnnotation	associated	PD	2222133, 26876947, 9587740
PA447230	HIV Infections	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	21106806, 11888582, 14685052, 15024131, 15247625, 16868443, 18184080, 18256392, 19104471, 19195327, 21091860, 22197535, 24911354, 25877443, 25934581, 27403179, 27530904
PA448004	abacavir	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	11888582, 11943262, 12409746, 15016610, 15247625, 16758424, 17075282, 17356469, 17545699, 18025891, 18256392, 18444831, 18479171, 18637831, 19696695, 21091860, 21412232, 22197535, 22722860, 23132554, 10449301, 11888582, 15024131, 15247625, 18184080, 18256392, 19195327, 21091860, 22197535, 22378157, 24433361, 24561393, 25674793, 25874872, 25877443, 25934581, 26604812, 27403179, 27530904
PA448015	acetaminophen	Chemical	VariantAnnotation	not associated	PD	21545408
PA448018	acetazolamide	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD	21342230
PA448320	allopurinol	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	18192896, 18256392, 18637831, 19018717, 19696695, 20536296, 21301380, 21393610, 21545408, 21790926, 21912425, 22348415, 22909208, 23132554, 23381951, 23600531, 23669020, 24591375, 7794310, 17075282, 17587850, 18192896, 19002350, 19018717, 19483528, 19696695, 21301380, 21393610, 21545408, 21790926, 21906289, 21912425, 22017528, 22348415, 22901319, 22909208, 23232549, 23280169, 23600531, 23669020, 24152157, 24591375, 24858023, 24915143, 25115449, 25257159, 25327504, 25566896, 25899558, 26104483, 26655481, 26937673, 26996548, 28509689, 28857441, 30383575, 32433341
PA448406	amoxicillin	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	30664875
PA448785	carbamazepine	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	14659971, 15024534, 15057820, 16415921, 16538176, 16981842, 17896897, 18636788, 18637831, 19018717, 19029983, 19109108, 19915237, 20001755, 20235791, 20345939, 20390258, 20536296, 20637045, 20833111, 21068649, 21071176, 21149285, 21169036, 21204807, 21216202, 21244392, 21306565, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22322005, 22348435, 22722860, 22818943, 22909208, 23159358, 23551241, 23692434, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24597466, 24897291, 25096692, 7794310, 9333104, 10629466, 15057820, 16415921, 16538176, 16981842, 17509004, 18637831, 19002350, 19018717, 19694795, 19915237, 20345939, 20833111, 21204807, 21244392, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22211527, 22348435, 22429379, 22500513, 23132554, 23551241, 23692434, 23695185, 23712814, 23830818, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24885933, 24897291, 25266342, 25305458, 25355835, 25495410, 25647819, 26319500, 27020614, 27096699, 27888155, 28570299, 29076187
PA449035	clindamycin	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	27527109
PA449061	clozapine	Chemical	VariantAnnotation	associated	PD	2222133, 26876947, 9587740
PA449211	dapsone	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	23604100, 24152261, 28885988, 29458119, 29512326
PA450037	interferon beta-1a	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	27020477
PA450163	lamivudine	Chemical	VariantAnnotation	associated	PD
PA450164	lamotrigine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	19668019, 20235791, 21071176, 21306565, 22258364, 23692434, 23830818, 24897291, 25327504, 25428396, 25495410, 25647819, 27888155
PA450413	methazolamide	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD	9109770, 20504258, 25918017, 25970075, 30242287, 9109770
PA450422	methimazole	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	26151496, 26599303
PA450519	minocycline	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD
PA450616	nevirapine	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PD	16868443, 19104471, 21505298, 24911354, 25361850, 25714001, 28819312
PA450732	oxcarbazepine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PD	22818943, 18785891, 19321411, 20235791, 21169036, 22013310, 22429379, 22818943, 24496695, 24897291, 27666425, 29629814
PA450911	phenobarbital	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation	ambiguous	PD	19002350, 19018717, 22429379, 23551241, 23692434, 24236482, 24496695
PA450947	phenytoin	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	14659971, 15024534, 15057820, 16538176, 16981842, 17896897, 18256392, 18636788, 18637831, 19018717, 19029983, 19109108, 19696695, 19915237, 20001755, 20235791, 20345939, 20390258, 20536296, 20637045, 20833111, 21068649, 21071176, 21149285, 21169036, 21204807, 21216202, 21244392, 21306565, 21397523, 21424386, 21428768, 21676164, 21917426, 22053601, 22322005, 22348435, 22722860, 22818943, 22909208, 23132554, 23159358, 23551241, 23692434, 23884208, 24225276, 24268988, 24322785, 24336023, 24394201, 24399721, 24496695, 24597466, 24897291, 25096692, 7794310, 9333104, 10629466, 18637831, 19002350, 19018717, 20235791, 21216202, 21334226, 22429379, 22500513, 23025739, 23551241, 23692434, 24236482, 24897291, 25096692, 25099164, 25305458, 25647819, 26927288, 26928377, 28391407
PA451156	propylthiouracil	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	26151496, 26599303
PA451241	ribavirin	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGene	associated	PD	23360626, 12873589, 23360626
PA451494	stavudine	Chemical	VariantAnnotation	associated	PD
PA451547	sulfasalazine	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	25303297
PA451686	ticlopidine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	17339877
PA451846	valproic acid	Chemical	VariantAnnotation	not associated	PD	23692434, 25647819
PA451978	zonisamide	Chemical	VariantAnnotation	not associated	PD	19018717, 24236482
PA451999	interferons	Chemical	VipGene	associated		23360626

References

Pubmed ID	Year	Title	Citations
37134231	2024	A Review of Laboratory Practices Using the HLA-B27 Survey by the College of American Pathologists: How Important Is Allele-Level Typing?	2
37406822	2024	The protective association of HLA-B∗52:01, HLA-C∗12:02, and DQB1∗06:01 alleles with severe acute hepatitis of unknown origin in Japanese children.	0
37552102	2024	HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.	2
37756371	2024	No Association Between HLA-B*57:01 and Prevalence and/or Outcome of Progressive Multifocal Leukoencephalopathy in a French Nationwide Human Immunodeficiency Virus Cohort.	0
37972805	2024	Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction.	0
38112753	2024	[The role of HLA-B27 in the pathogenesis and diagnosis of axial spondyloarthritis : 50 years after discovery of the strong genetic association].	0
38171559	2024	[Genetic analysis of a Chinese pedigree with an allele dropout at the HLA-B locus].	0
38285781	2024	HLA-B58 and HLA-B27 Play a Role in the Development of Acute Leukemia: A Case Control Study.	0
38305022	2024	Update on HLA-B*15:02 allele associated with adverse drug reactions.	0
38385410	2024	HLA-B*51 Frequency in Transplant Patients and Donors.	0
38674456	2024	HLA-B and C Expression Contributes to COVID-19 Disease Severity within a South African Cohort.	0
38728374	2024	HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension.	0
38783377	2024	Comparative study of two laboratory techniques for the detection of HLA-B27 in patients with axial spondyloarthritis: a cross-sectional analysis.	0
37134231	2024	A Review of Laboratory Practices Using the HLA-B27 Survey by the College of American Pathologists: How Important Is Allele-Level Typing?	2
37406822	2024	The protective association of HLA-B∗52:01, HLA-C∗12:02, and DQB1∗06:01 alleles with severe acute hepatitis of unknown origin in Japanese children.	0

Citation

Dessen P

HLA-B (major histocompatibility complex, class I, B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46594/hla-b-(major-histocompatibility-complex-class-i-b)

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