BCL9 (B-cell CLL/lymphoma 9)
2003-02-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Description
10 exons spanning 85 kb.
Transcription
transcripts of 1.6, 4.2, and 6.3 kb.
Proteins
Description
1426 amino acids, 149 kDa.
Expression
wide
Function
Binds to beta-catenin required for Wnt signal transduction
Homology
drosophila segment polarity gene legless, encoding wingless-armadillo (WNT - beta-catenin) signaling molecule
Implicated in
Entity name
t(1;14)(q21;q32) and t(1;22)(q21;q11)
Disease
acute lymphoblastic leukemia and non Hodgkin lymphoma
Hybrid gene
BCL9 is juxtaposed either with the immunoglobulin heavy chain locus IgH (14q32) or the lambda light-chain locus Igl (22q11)
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11955446 | 2002 | Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. | Kramps T et al |
| 9490669 | 1998 | Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. | Willis TG et al |
Other Information
Locus ID:
NCBI: 607
MIM: 602597
HGNC: 1008
Ensembl: ENSG00000116128
Variants:
dbSNP: 607
ClinVar: 607
TCGA: ENSG00000116128
COSMIC: BCL9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116128 | ENST00000234739 | O00512 |
| ENSG00000116128 | ENST00000234739 | A0A024QYY4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36803362 | 2023 | Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma. | 1 |
| 36803362 | 2023 | Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma. | 1 |
| 35027586 | 2022 | Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9. | 6 |
| 35027586 | 2022 | Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9. | 6 |
| 33767438 | 2021 | BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. | 15 |
| 33838016 | 2021 | miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2. | 24 |
| 33862557 | 2021 | Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer. | 4 |
| 33974352 | 2021 | LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling. | 9 |
| 34545187 | 2021 | The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis. | 12 |
| 33767438 | 2021 | BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. | 15 |
| 33838016 | 2021 | miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2. | 24 |
| 33862557 | 2021 | Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer. | 4 |
| 33974352 | 2021 | LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling. | 9 |
| 34545187 | 2021 | The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis. | 12 |
| 31911584 | 2020 | BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins. | 21 |
Citation
Jean-Loup Huret ; Sylvie Senon
BCL9 (B-cell CLL/lymphoma 9)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/466/bcl9-(b-cell-cll-lymphoma-9)
