PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)

2007-03-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
CALNB1,CNB,CNB1
FUSION GENES

Other Information

Locus ID:

NCBI: 5534
MIM: 601302
HGNC: 9317
Ensembl: ENSG00000221823

Variants:

dbSNP: 5534
ClinVar: 5534
TCGA: ENSG00000221823
COSMIC: PPP3R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000221823ENST00000234310P63098
ENSG00000221823ENST00000409377F6U1T9
ENSG00000221823ENST00000409752D3YTA9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Calcium signaling pathwayKEGGko04020
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
VEGF signaling pathwayKEGGko04370
Natural killer cell mediated cytotoxicityKEGGko04650
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
Long-term potentiationKEGGko04720
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Calcium signaling pathwayKEGGhsa04020
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
VEGF signaling pathwayKEGGhsa04370
Natural killer cell mediated cytotoxicityKEGGhsa04650
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
Long-term potentiationKEGGhsa04720
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activationREACTOMER-HSA-5607763
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA248NFKB1GenePathwayassociated23922006
PA296RELAGenePathwayassociated23922006
PA31582NFATC1GenePathwayassociated23922006
PA31583NFATC2GenePathwayassociated23922006
PA31584NFATC4GenePathwayassociated23922006
PA31600NFKB2GenePathwayassociated23922006
PA34321RELGenePathwayassociated23922006
PA34322RELBGenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208623292010SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.62
192859442009A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.49
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
228146002012Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.43
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
216744742011Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.24
196530052009The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes.22
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
182964422008The secondary structure of calcineurin regulatory region and conformational change induced by calcium/calmodulin binding.16

Citation

Dessen P

PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46614/ppp3r1-(protein-phosphatase-3-regulatory-subunit-b-alpha)