DiBEST Department (Biologia, Ecologia, Scienze della Terra), via Pietro Bucci, Cubo 6C 87036 Arcavacata di Rende, CS,Italy firstname.lastname@example.org; email@example.com
The DUSP26 gene encodes for an atypical dual specificity phosphatase commonly referred to as Dusp26 or MPK8. Although its physiological role is poorly understood, different substrates have been reported to be dephosphorylated by Dusp26, including p53, Kif3, Erk and p38. In this report we summarize the current knowledge on DUSP26 gene, its transcripts, the encoded protein and its function in normal and tumorous tissues. Notably, the phosphatase is overexpressed in neuroblastoma and ATC cells, where it promotes chemoresistance by inhibiting the p53 and the p38 proteins, respectively. Dusp26 represents a promising novel therapeutic target to be integrated with others and with conventional medicine, to improve survival outcome in patients and to reduce toxicity.
Simona Panni ; Raffaella Gallo
DUSP26 (dual specificity phosphatase 26)
Atlas Genet Cytogenet Oncol Haematol. 2015-05-01
Online version: http://atlasgeneticsoncology.org/gene/46622/dusp26-(dual-specificity-phosphatase-26)