NFYC (nuclear transcription factor Y subunit gamma)

2007-04-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
CBF-C,CBFC,H1TF2A,HAP5,HSM,NF-YC
FUSION GENES

Other Information

Locus ID:

NCBI: 4802
MIM: 605344
HGNC: 7806
Ensembl: ENSG00000066136

Variants:

dbSNP: 4802
ClinVar: 4802
TCGA: ENSG00000066136
COSMIC: NFYC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066136ENST00000308733Q13952
ENSG00000066136ENST00000372651Q13952
ENSG00000066136ENST00000372652Q13952
ENSG00000066136ENST00000372653Q13952
ENSG00000066136ENST00000372654Q13952
ENSG00000066136ENST00000372669Q5T6K5
ENSG00000066136ENST00000414185H0Y803
ENSG00000066136ENST00000416859A0A0A0MT00
ENSG00000066136ENST00000425457Q13952
ENSG00000066136ENST00000427410Q13952
ENSG00000066136ENST00000440226Q13952
ENSG00000066136ENST00000447388Q13952
ENSG00000066136ENST00000453631Q5T6K7
ENSG00000066136ENST00000456393Q13952
ENSG00000066136ENST00000525290E9PI99
ENSG00000066136ENST00000530965E9PL11
ENSG00000066136ENST00000531464E9PQR2
ENSG00000066136ENST00000534399E9PJA8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Antigen processing and presentationKEGGhsa04612
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
ATF6 (ATF6-alpha) activates chaperonesREACTOMER-HSA-381033
ATF6 (ATF6-alpha) activates chaperone genesREACTOMER-HSA-381183
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

References

Pubmed IDYearTitleCitations
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
124017882003The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.97
233327512013Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.74
145864022003p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.45
124827522003Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.26
259655742015Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.21
236579742014Adipogenic differentiation is impaired in replicative senescent human subcutaneous adipose-derived stromal/progenitor cells.20
224128932012Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.16
195597822009Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers.10
196901682009NF-YC complexity is generated by dual promoters and alternative splicing.7

Citation

Dessen P

NFYC (nuclear transcription factor Y subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46637/nfyc-(nuclear-transcription-factor-y-subunit-gamma)