Identity
HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
DDX2A,EIF-4A,EIF4A,eIF-4A-I,eIF4A-I
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1973
MIM: 602641
HGNC: 3282
Ensembl: ENSG00000161960
Variants:
dbSNP: 1973
ClinVar: 1973
TCGA: ENSG00000161960
COSMIC: EIF4A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38738857 | 2024 | mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells. | 0 |
| 38738857 | 2024 | mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells. | 0 |
| 36727461 | 2023 | eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. | 5 |
| 36768380 | 2023 | eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma. | 1 |
| 36727461 | 2023 | eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. | 5 |
| 36768380 | 2023 | eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma. | 1 |
| 35361883 | 2022 | Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer. | 7 |
| 36552834 | 2022 | eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model. | 5 |
| 35361883 | 2022 | Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer. | 7 |
| 36552834 | 2022 | eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model. | 5 |
| 33632898 | 2021 | Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules. | 17 |
| 33632898 | 2021 | Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules. | 17 |
| 32014999 | 2020 | A comparative study of small molecules targeting eIF4A. | 17 |
| 32147684 | 2020 | High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer. | 24 |
| 32392243 | 2020 | ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection. | 4 |
Citation
Dessen P
EIF4A1 (eukaryotic translation initiation factor 4A1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46639/eif4a1-(eukaryotic-translation-initiation-factor-4a1)
