HIGD1A (HIG1 hypoxia inducible domain family member 1A)

2007-04-01  

Identity

HGNC
HIGD1A
LOCATION
3p22.1
LOCUSID
25994
ALIAS
HIG1,RCF1a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25994
MIM: 618623
HGNC: 29527
Ensembl: ENSG00000181061

Variants:

dbSNP: 25994
ClinVar: 25994
TCGA: ENSG00000181061
COSMIC: HIGD1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181061ENST00000321331Q9Y241
ENSG00000181061ENST00000321331A0A024R2M9
ENSG00000181061ENST00000418900Q9Y241
ENSG00000181061ENST00000418900A0A024R2M9
ENSG00000181061ENST00000430190C9JNU6
ENSG00000181061ENST00000452906Q9Y241

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380532822024The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B.0
380532822024The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B.0
368044672023HIG1 domain family member 1A is a crucial regulator of disorders associated with hypoxia.3
370866312023HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma.0
371858502023Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.1
368044672023HIG1 domain family member 1A is a crucial regulator of disorders associated with hypoxia.3
370866312023HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma.0
371858502023Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.1
347870612021HIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells.3
347870612021HIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells.3
319146022020Higd1a improves respiratory function in the models of mitochondrial disorder.10
323750442020Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.31
319146022020Higd1a improves respiratory function in the models of mitochondrial disorder.10
323750442020Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.31
310894102019Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.9

Citation

Dessen P

HIGD1A (HIG1 hypoxia inducible domain family member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46646/higd1a-(hig1-hypoxia-inducible-domain-family-member-1a)