COPS3 (COP9 signalosome subunit 3)

2007-04-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
CSN3,SGN3
FUSION GENES

Other Information

Locus ID:

NCBI: 8533
MIM: 604665
HGNC: 2239
Ensembl: ENSG00000141030

Variants:

dbSNP: 8533
ClinVar: 8533
TCGA: ENSG00000141030
COSMIC: COPS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141030ENST00000268717Q9UNS2
ENSG00000141030ENST00000417352C9JLV5
ENSG00000141030ENST00000439936H7C3P9
ENSG00000141030ENST00000477299J3QKR0
ENSG00000141030ENST00000492672J3QS85
ENSG00000141030ENST00000495640K7EJF9
ENSG00000141030ENST00000539941Q9UNS2
ENSG00000141030ENST00000577210J3QL22
ENSG00000141030ENST00000577246J3QL22
ENSG00000141030ENST00000578317J3QS85
ENSG00000141030ENST00000579716K7ELN6
ENSG00000141030ENST00000583160K7ES36
ENSG00000141030ENST00000584216J3KTQ1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
299701152018Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy.7
214368692011RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells.6
222379562012Inhibition of Csn3 expression induces growth arrest and apoptosis of hepatocellular carcinoma cells.5
294776182018Overexpression of COPS3 promotes clear cell renal cell carcinoma progression via regulation of Phospho-AKT(Thr308), Cyclin D1 and Caspase-3.4
315092892019Knockdown of COPS3 inhibits the progress of prostate cancer through reducing phosphorylated p38 MAPK expression and impairs the epithelial-mesenchymal transition process.1
288914682017Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.0

Citation

Dessen P

COPS3 (COP9 signalosome subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46656/cops3-(cop9-signalosome-subunit-3)