FRMD4A (FERM domain containing 4A)

2007-04-01  

Identity

HGNC
LOCATION
10p13
LOCUSID
ALIAS
CCAFCA,FRMD4,bA295P9.4
FUSION GENES

Other Information

Locus ID:

NCBI: 55691
MIM: 616305
HGNC: 25491
Ensembl: ENSG00000151474

Variants:

dbSNP: 55691
ClinVar: 55691
TCGA: ENSG00000151474
COSMIC: FRMD4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151474ENST00000264546Q5T376
ENSG00000151474ENST00000357447Q9P2Q2
ENSG00000151474ENST00000475141S4R324
ENSG00000151474ENST00000477221A0A0J9YXB2
ENSG00000151474ENST00000493380S4R3Y6
ENSG00000151474ENST00000495956A0A0J9YYA7
ENSG00000151474ENST00000632570A0A0J9YWI3
ENSG00000151474ENST00000640906A0A1W2PQE7
ENSG00000151474ENST00000648400A0A3B3ISM9
ENSG00000151474ENST00000648761A0A3B3IRJ0
ENSG00000151474ENST00000649099A0A3B3ISM9
ENSG00000151474ENST00000649155A0A3B3ISM9
ENSG00000151474ENST00000649246A0A3B3ISM9
ENSG00000151474ENST00000649423A0A3B3IS86
ENSG00000151474ENST00000649947A0A3B3ISM0
ENSG00000151474ENST00000650014A0A3B3ISR1
ENSG00000151474ENST00000650137A0A3B3ISB3

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
220062182012Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.36
224306742013Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.28
225645252012FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.19
253880052015A syndrome of congenital microcephaly, intellectual disability and dysmorphism with a homozygous mutation in FRMD4A.6
270447542016FRMD4A-cytohesin signaling modulates the cellular release of tau.6
276663462016FRMD4A: A potential therapeutic target for the treatment of tongue squamous cell carcinoma.2

Citation

Dessen P

FRMD4A (FERM domain containing 4A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46677/frmd4a-(ferm-domain-containing-4a)