RNF144B (ring finger protein 144B)

2007-04-01  

Identity

HGNC
RNF144B
LOCATION
6p22.3
LOCUSID
255488
ALIAS
IBRDC2,PIR2,bA528A10.3,p53RFP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 255488
MIM: 618869
HGNC: 21578
Ensembl: ENSG00000137393

Variants:

dbSNP: 255488
ClinVar: 255488
TCGA: ENSG00000137393
COSMIC: RNF144B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137393ENST00000259939Q7Z419

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386851002024The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.0
386851002024The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.0
356995952022RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia.4
356995952022RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia.4
315092992019RNF144B inhibits LPS-induced inflammatory responses via binding TBK1.6
315092992019RNF144B inhibits LPS-induced inflammatory responses via binding TBK1.6
297249952018Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.6
297249952018Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.6
275244172017miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.18
275244172017miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.18
231283962013PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.13
231283962013PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.13
203000622010IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.42
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206159662010Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.43

Citation

Dessen P

RNF144B (ring finger protein 144B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46739/rnf144b-(ring-finger-protein-144b)