EGLN3 (egl-9 family hypoxia inducible factor 3)

2007-04-01  

Identity

HGNC
EGLN3
LOCATION
14q13.1
LOCUSID
112399
ALIAS
HIFP4H3,HIFPH3,PHD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 112399
MIM: 606426
HGNC: 14661
Ensembl: ENSG00000129521

Variants:

dbSNP: 112399
ClinVar: 112399
TCGA: ENSG00000129521
COSMIC: EGLN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129521ENST00000250457Q9H6Z9
ENSG00000129521ENST00000487915G3V3M1
ENSG00000129521ENST00000547327F8VR39
ENSG00000129521ENST00000553215F8W1G2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renal cell carcinomaKEGGko05211
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
HIF-1 signaling pathwayKEGGhsa04066
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176

References

Pubmed IDYearTitleCitations
381846922024EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.0
384006732024Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.1
381846922024EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.0
384006732024Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.1
368825232023E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.1
368825232023E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.1
350886612022PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma.1
351246972022Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth.18
350886612022PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma.1
351246972022Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth.18
335715272021Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.4
337996862021Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo.3
341121672021USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.7
335715272021Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.4
337996862021Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo.3

Citation

Dessen P

EGLN3 (egl-9 family hypoxia inducible factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46747/egln3-(egl-9-family-hypoxia-inducible-factor-3)