HSPA12B (heat shock protein family A (Hsp70) member 12B)

2007-04-01  

Identity

HGNC
HSPA12B
LOCATION
20p13
LOCUSID
116835
ALIAS
C20orf60
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 116835
MIM: 610702
HGNC: 16193
Ensembl: ENSG00000132622

Variants:

dbSNP: 116835
ClinVar: 116835
TCGA: ENSG00000132622
COSMIC: HSPA12B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132622ENST00000254963Q96MM6
ENSG00000132622ENST00000399701Q5JX83

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324577532020Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.21
324577532020Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.21
291154872018MiR-4505 aggravates lipopolysaccharide-induced vascular endothelial injury by targeting heat shock protein A12B.8
291154872018MiR-4505 aggravates lipopolysaccharide-induced vascular endothelial injury by targeting heat shock protein A12B.8
270839522016Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.15
276443172016HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism.28
270839522016Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.15
276443172016HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism.28
255450502015HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells.16
259091702015HSPA12B: a novel facilitator of lung tumor growth.11
264286652015HSPA12B regulates SSeCKS-mediated astrocyte inflammatory activation in neuroinflammation.3
255450502015HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells.16
259091702015HSPA12B: a novel facilitator of lung tumor growth.11
264286652015HSPA12B regulates SSeCKS-mediated astrocyte inflammatory activation in neuroinflammation.3
249774122014Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis.6

Citation

Dessen P

HSPA12B (heat shock protein family A (Hsp70) member 12B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46775/hspa12b-(heat-shock-protein-family-a-(hsp70)-member-12b)