BICD2 (BICD cargo adaptor 2)

2007-04-01  

Identity

HGNC
LOCATION
9q22.31
LOCUSID
ALIAS
SMALED2,SMALED2A,SMALED2B,bA526D8.1
FUSION GENES

Other Information

Locus ID:

NCBI: 23299
MIM: 609797
HGNC: 17208
Ensembl: ENSG00000185963

Variants:

dbSNP: 23299
ClinVar: 23299
TCGA: ENSG00000185963
COSMIC: BICD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185963ENST00000356884Q8TD16
ENSG00000185963ENST00000375512Q8TD16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385263252024m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.1
387197482024Molecular mechanism for recognition of the cargo adapter Rab6(GTP) by the dynein adapter BicD2.0
385263252024m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.1
387197482024Molecular mechanism for recognition of the cargo adapter Rab6(GTP) by the dynein adapter BicD2.0
369305952023Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.3
370477812023Microscopic and Biochemical Hallmarks of BICD2-Associated Muscle Pathology toward the Evaluation of Novel Variants.0
369305952023Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.3
370477812023Microscopic and Biochemical Hallmarks of BICD2-Associated Muscle Pathology toward the Evaluation of Novel Variants.0
358584352022Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice.4
360685402022Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy.2
361503792022In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2.3
358584352022Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice.4
360685402022Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy.2
361503792022In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2.3
333821582021circBICD2 targets miR-149-5p/IGF2BP1 axis to regulate oral squamous cell carcinoma progression.10

Citation

Dessen P

BICD2 (BICD cargo adaptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46791/bicd2-(bicd-cargo-adaptor-2)