NR1D2 (nuclear receptor subfamily 1 group D member 2)

2007-04-01  

Identity

HGNC
NR1D2
LOCATION
3p24.2
LOCUSID
9975
ALIAS
BD73,EAR-1R,REVERBB,REVERBbeta,RVR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9975
MIM: 602304
HGNC: 7963
Ensembl: ENSG00000174738

Variants:

dbSNP: 9975
ClinVar: 9975
TCGA: ENSG00000174738
COSMIC: NR1D2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174738ENST00000312521Q14995
ENSG00000174738ENST00000312521F1D8P2
ENSG00000174738ENST00000383773Q6NSM0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180378872007Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.219
211231682011Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}.38
250236982015Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells.29
228289412013Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples.17
266706072016High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor.17
203484642010Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder.13
241737682014REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.13
179969652008The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.8
248724112014Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.8
266160492016Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells.8

Citation

Dessen P

NR1D2 (nuclear receptor subfamily 1 group D member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46810/nr1d2-(nuclear-receptor-subfamily-1-group-d-member-2)