Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
MST092,MST106,MST129,MSTP032,MSTP092,MSTP106,MSTP129
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8490
MIM: 603276
HGNC: 10001
Ensembl: ENSG00000232995
Variants:
dbSNP: 8490
ClinVar: 8490
TCGA: ENSG00000232995
COSMIC: RGS5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by GPCR | REACTOME | R-HSA-372790 |
| GPCR downstream signaling | REACTOME | R-HSA-388396 |
| G alpha (i) signalling events | REACTOME | R-HSA-418594 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 25069475 | |
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 25069475 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 25069475 | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 25069475 | |
| PA450198 | leucovorin | Chemical | ClinicalAnnotation | associated | PD | 25069475 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37594134 | 2023 | Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation. | 1 |
| 37594134 | 2023 | Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation. | 1 |
| 35681135 | 2022 | Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism. | 0 |
| 36111549 | 2022 | RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. | 7 |
| 35681135 | 2022 | Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism. | 0 |
| 36111549 | 2022 | RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. | 7 |
| 31605122 | 2021 | Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. | 10 |
| 32191345 | 2021 | Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling. | 33 |
| 34212534 | 2021 | Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma. | 4 |
| 34359918 | 2021 | RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. | 5 |
| 31605122 | 2021 | Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. | 10 |
| 32191345 | 2021 | Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling. | 33 |
| 34212534 | 2021 | Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma. | 4 |
| 34359918 | 2021 | RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. | 5 |
| 32041970 | 2020 | Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation. | 3 |
Citation
Dessen P
RGS5 (regulator of G protein signaling 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46825/rgs5
