Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79961
MIM: 615111
HGNC: 26192
Ensembl: ENSG00000162777
Variants:
dbSNP: 79961
ClinVar: 79961
TCGA: ENSG00000162777
COSMIC: DENND2D
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162777 | ENST00000357640 | Q9H6A0 |
| ENSG00000162777 | ENST00000357640 | A0A024R0G2 |
| ENSG00000162777 | ENST00000369752 | Q9H6A0 |
| ENSG00000162777 | ENST00000369752 | A0A024R0H5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| RAB GEFs exchange GTP for GDP on RABs | REACTOME | R-HSA-8876198 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27929118 | 2016 | Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma. | 100 |
| 27929118 | 2016 | Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma. | 100 |
| 24695972 | 2015 | Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. | 24 |
| 24695972 | 2015 | Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. | 24 |
| 24189587 | 2014 | Downregulation of DENND2D by promoter hypermethylation is associated with early recurrence of hepatocellular carcinoma. | 20 |
| 24317529 | 2014 | Reduced expression of DENND2D through promoter hypermethylation is an adverse prognostic factor in squamous cell carcinoma of the esophagus. | 10 |
| 24189587 | 2014 | Downregulation of DENND2D by promoter hypermethylation is associated with early recurrence of hepatocellular carcinoma. | 20 |
| 24317529 | 2014 | Reduced expression of DENND2D through promoter hypermethylation is an adverse prognostic factor in squamous cell carcinoma of the esophagus. | 10 |
| 23182661 | 2013 | Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. | 9 |
| 23182661 | 2013 | Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. | 9 |
| 18677770 | 2008 | Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. | 13 |
| 18677770 | 2008 | Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. | 13 |
Citation
Dessen P
DENND2D (DENN domain containing 2D)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46828/dennd2d-(denn-domain-containing-2d)
