HDAC8 (histone deacetylase 8)

2007-04-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
CDA07,CDLS5,HD8,HDACL1,KDAC8,MRXS6,RPD3,WTS
FUSION GENES

Other Information

Locus ID:

NCBI: 55869
MIM: 300269
HGNC: 13315
Ensembl: ENSG00000147099

Variants:

dbSNP: 55869
ClinVar: 55869
TCGA: ENSG00000147099
COSMIC: HDAC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147099ENST00000373554Q9BY41
ENSG00000147099ENST00000373556Q9BY41
ENSG00000147099ENST00000373559Q9BY41
ENSG00000147099ENST00000373560A6NGT0
ENSG00000147099ENST00000373568A6NGJ7
ENSG00000147099ENST00000373571A6NMT1
ENSG00000147099ENST00000373573Q9BY41
ENSG00000147099ENST00000373583A6NFW1
ENSG00000147099ENST00000373589Q9BY41
ENSG00000147099ENST00000412342F8WCG4
ENSG00000147099ENST00000415409E7EVA8
ENSG00000147099ENST00000421523C9J8F0
ENSG00000147099ENST00000436675E7EW22
ENSG00000147099ENST00000439122Q9BY41
ENSG00000147099ENST00000470998A0A3B3ISP0
ENSG00000147099ENST00000647594A0A3B3IRI9
ENSG00000147099ENST00000647606A0A3B3ISB8
ENSG00000147099ENST00000647654A0A3B3IT30
ENSG00000147099ENST00000647859A0A3B3IRI9
ENSG00000147099ENST00000647886A0A3B3IS68
ENSG00000147099ENST00000647974A0A3B3ISG7
ENSG00000147099ENST00000647980A0A3B3ITZ3
ENSG00000147099ENST00000648036A0A3B3IRZ8
ENSG00000147099ENST00000648139A0A3B3IRJ3
ENSG00000147099ENST00000648276A0A3B3IT98
ENSG00000147099ENST00000648298A0A3B3IRP8
ENSG00000147099ENST00000648452A0A3B3ISJ4
ENSG00000147099ENST00000648459A0A3B3IU52
ENSG00000147099ENST00000648504A0A3B3IT95
ENSG00000147099ENST00000648577A0A3B3IRJ8
ENSG00000147099ENST00000648711A0A3B3IU62
ENSG00000147099ENST00000648731A0A3B3ITV2
ENSG00000147099ENST00000648834A0A3B3ISS7
ENSG00000147099ENST00000648850A0A3B3ISN6
ENSG00000147099ENST00000648870A0A3B3IT84
ENSG00000147099ENST00000648939A0A3B3ISS7
ENSG00000147099ENST00000648962A0A3B3ISY0
ENSG00000147099ENST00000649097A0A3B3IT04
ENSG00000147099ENST00000649116Q9BY41
ENSG00000147099ENST00000649181A0A3B3IUD1
ENSG00000147099ENST00000649242A0A3B3IRJ8
ENSG00000147099ENST00000649274A0A3B3IS08
ENSG00000147099ENST00000649518A0A3B3IRJ8
ENSG00000147099ENST00000649543A0A3B3IRJ8
ENSG00000147099ENST00000649752A0A3B3ISE4
ENSG00000147099ENST00000650076A0A3B3IRZ0
ENSG00000147099ENST00000650126A0A3B3IU01
ENSG00000147099ENST00000650471A0A3B3IU21
ENSG00000147099ENST00000650604A0A3B3IS37
ENSG00000147099ENST00000650636A0A3B3IS93

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228857002012HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.191
154775952004Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.168
182566832008A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.116
177863342007Expression profile of class I histone deacetylases in human cancer tissues.96
177214402007Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.94
191180362009Histone deacetylase 8 in neuroblastoma tumorigenesis.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
157721152005Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility.74
190532822008Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.71
166813892006Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.62

Citation

Dessen P

HDAC8 (histone deacetylase 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46856/hdac8-(histone-deacetylase-8)