Identity
HGNC
LOCATION
18q21.31
LOCUSID
ALIAS
NEDD4-2,NEDD4.2,PVNH7,RSP5,hNEDD4-2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23327
MIM: 606384
HGNC: 7728
Ensembl: ENSG00000049759
Variants:
dbSNP: 23327
ClinVar: 23327
TCGA: ENSG00000049759
COSMIC: NEDD4L
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA151249535 | diuretics | Chemical | ClinicalAnnotation | associated | PD | 18591455, 21052022 | |
| PA162403013 | SGK1 | Gene | Pathway | associated | 23788015 | ||
| PA305 | SCNN1A | Gene | Pathway | associated | 23788015 | ||
| PA306 | SCNN1B | Gene | Pathway | associated | 23788015 | ||
| PA307 | SCNN1G | Gene | Pathway | associated | 23788015 | ||
| PA321 | SLC12A3 | Gene | Pathway | associated | 23788015 | ||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 18591455, 19635985, 21052022 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 23809733 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 23809733 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 18591455, 19635985, 21052022 | |
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37962894 | 2024 | Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2. | 1 |
| 38155530 | 2024 | Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations. | 0 |
| 38302612 | 2024 | METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke. | 0 |
| 38309503 | 2024 | NEDD4L intramolecular interactions regulate its auto and substrate Na(V)1.5 ubiquitination. | 0 |
| 38526036 | 2024 | NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells. | 1 |
| 38831335 | 2024 | NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression. | 0 |
| 37962894 | 2024 | Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2. | 1 |
| 38155530 | 2024 | Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations. | 0 |
| 38302612 | 2024 | METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke. | 0 |
| 38309503 | 2024 | NEDD4L intramolecular interactions regulate its auto and substrate Na(V)1.5 ubiquitination. | 0 |
| 38526036 | 2024 | NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells. | 1 |
| 38831335 | 2024 | NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression. | 0 |
| 36136271 | 2023 | NEDD4L represses prostate cancer cell proliferation via modulating PHF8 through the ubiquitin-proteasome pathway. | 3 |
| 36257596 | 2023 | Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis. | 6 |
| 36857592 | 2023 | Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU. | 1 |
Citation
Dessen P
NEDD4L (NEDD4 like E3 ubiquitin protein ligase)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46861/nedd4l-(nedd4-like-e3-ubiquitin-protein-ligase)
