Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9025
MIM: 611685
HGNC: 10071
Ensembl: ENSG00000112130
Variants:
dbSNP: 9025
ClinVar: 9025
TCGA: ENSG00000112130
COSMIC: RNF8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 30071039 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 30071039 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 30071039 | |
| PA451743 | trastuzumab | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 30071039 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37154586 | 2023 | RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity. | 1 |
| 37468549 | 2023 | CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. | 1 |
| 37154586 | 2023 | RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity. | 1 |
| 37468549 | 2023 | CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. | 1 |
| 35428760 | 2022 | RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression. | 5 |
| 35428760 | 2022 | RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression. | 5 |
| 33205415 | 2021 | The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells. | 0 |
| 33710666 | 2021 | RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage. | 7 |
| 33205415 | 2021 | The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells. | 0 |
| 33710666 | 2021 | RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage. | 7 |
| 32031738 | 2020 | RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60. | 7 |
| 32427332 | 2020 | RNF8 has both KU-dependent and independent roles in chromosomal break repair. | 13 |
| 32453758 | 2020 | RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia. | 6 |
| 32502756 | 2020 | RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells. | 3 |
| 32549753 | 2020 | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation. | 17 |
Citation
Dessen P
RNF8 (ring finger protein 8)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46867/rnf8-(ring-finger-protein-8)
