RNF138 (ring finger protein 138)

2007-04-01 Affiliation

Identity

HGNC

RNF138

LOCATION

18q12.1

LOCUSID

51444

ALIAS

HSD-4,NARF,STRIN,hNARF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51444
MIM: 616319
HGNC: 17765
Ensembl: ENSG00000134758

Variants:

dbSNP: 51444
ClinVar: 51444
TCGA: ENSG00000134758
COSMIC: RNF138

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134758	ENST00000257190	Q8WVD3
ENSG00000134758	ENST00000261593	Q8WVD3
ENSG00000134758	ENST00000261593	A0A140VJT9
ENSG00000134758	ENST00000577999	J3QLQ3
ENSG00000134758	ENST00000578107	J3KSI2
ENSG00000134758	ENST00000578914	J3KRU4
ENSG00000134758	ENST00000580499	J3QKM8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16714285	2006	NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).	51
26502055	2015	The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.	42
26502057	2015	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	35
29371697	2018	RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis.	7
22155992	2012	A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251.	5
27161866	2016	RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.	5
27195665	2016	Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway.	5
28167673	2017	Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Ca_v2.1 (P/Q-Type) Calcium Channels.	3
30272353	2018	Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway.	3

Citation

Dessen P

RNF138 (ring finger protein 138)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46877/rnf138-(ring-finger-protein-138)