PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3)

2007-04-01 Affiliation

Identity

HGNC

PRKAG3

LOCATION

2q35

LOCUSID

53632

ALIAS

AMPKG3,SMGMQTL

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 53632
MIM: 604976
HGNC: 9387
Ensembl: ENSG00000115592

Variants:

dbSNP: 53632
ClinVar: 53632
TCGA: ENSG00000115592
COSMIC: PRKAG3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115592	ENST00000233944	Q9UGI9
ENSG00000115592	ENST00000233944	A0A024R426
ENSG00000115592	ENST00000430489	C9JIC7
ENSG00000115592	ENST00000439262	Q9UGI9
ENSG00000115592	ENST00000439262	A0A024R426
ENSG00000115592	ENST00000470307	B4DUK8
ENSG00000115592	ENST00000529249	Q9UGI9
ENSG00000115592	ENST00000529249	A0A024R426

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Circadian rhythm	KEGG	ko04710
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Tight junction	KEGG	hsa04530
Circadian rhythm	KEGG	hsa04710
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
FoxO signaling pathway	KEGG	hsa04068
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	REACTOME	R-HSA-2151209
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Insulin resistance	KEGG	hsa04931
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Apelin signaling pathway	KEGG	hsa04371

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134983031	GPAM	Gene	Pathway	associated	22722338
PA142672073	CRTC2	Gene	Pathway	associated	22722338
PA189	HMGCR	Gene	Pathway	associated	22722338
PA24421	ACACA	Gene	Pathway	associated	22722338
PA24422	ACACB	Gene	Pathway	associated	22722338
PA30861	MLYCD	Gene	Pathway	associated	22722338
PA335	SREBF1	Gene	Pathway	associated	22722338
PA35879	SLC2A4	Gene	Pathway	associated	22722338
PA36198	STK11	Gene	Pathway	associated	22722338
PA37353	MLXIPL	Gene	Pathway	associated	22722338
PA37935	SIRT1	Gene	Pathway	associated	22722338
PA450395	metformin	Chemical	Pathway	associated	22722338
PA61	ATM	Gene	Pathway	associated	22722338

References

Pubmed ID	Year	Title	Citations
37506328	2023	AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores.	1
37506328	2023	AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores.	1
28302767	2017	Effect of different γ-subunit isoforms on the regulation of AMPK.	27
28582508	2017	Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.	5
28302767	2017	Effect of different γ-subunit isoforms on the regulation of AMPK.	27
28582508	2017	Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.	5
27866917	2016	PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population.	2
27866917	2016	PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population.	2
23396962	2013	Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.	13
23396962	2013	Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.	13
20821366	2011	Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.	10
20821366	2011	Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.	10
19836452	2010	Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells.	2
20473479	2010	Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.	10
20682687	2010	Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.	116

Citation

Dessen P

PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46886/prkag3-(protein-kinase-amp-activated-non-catalytic-subunit-gamma-3)