ACSS2 (acyl-CoA synthetase short chain family member 2)

2007-04-01  

Identity

HGNC
ACSS2
LOCATION
20q11.22
LOCUSID
55902
ALIAS
ACAS2,ACECS,ACS,ACSA,AceCS1,dJ1161H23.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55902
MIM: 605832
HGNC: 15814
Ensembl: ENSG00000131069

Variants:

dbSNP: 55902
ClinVar: 55902
TCGA: ENSG00000131069
COSMIC: ACSS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131069ENST00000253382Q9NR19
ENSG00000131069ENST00000360596Q9NR19
ENSG00000131069ENST00000473172C9JY31
ENSG00000131069ENST00000475459F8WDJ9
ENSG00000131069ENST00000477932F8WCJ4
ENSG00000131069ENST00000480274F8WC73
ENSG00000131069ENST00000480978B4DEH9
ENSG00000131069ENST00000481284F8WBQ7
ENSG00000131069ENST00000484354C9JXD9
ENSG00000131069ENST00000488172C9J7L5
ENSG00000131069ENST00000493805C9IYL0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD28550509
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21636554
PA448073ethanolChemicalClinicalAnnotationassociatedPD28550509
PA448803carboplatinChemicalClinicalAnnotationassociatedPD21636554
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21636554
PA449383docetaxelChemicalClinicalAnnotationassociatedPD21636554
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD21636554
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD21636554

References

Pubmed IDYearTitleCitations
367076252023ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells.7
380515852023ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules.3
367076252023ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells.7
380515852023ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules.3
351906422022O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.20
357774822022Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.7
351906422022O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.20
357774822022Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.7
343435652021Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.2
343435652021Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.2
310761062019Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma.6
317304052019miR-30a-GNG2 and miR-15b-ACSS2 Interaction Pairs May Be Potentially Crucial for Development of Abdominal Aortic Aneurysm by Influencing Inflammation.7
318145692019[Knockdown of ACSS2 inhibits invasion and migration of cervical cancer cells induced by nutrient stress and its mechanism].3
310761062019Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma.6
317304052019miR-30a-GNG2 and miR-15b-ACSS2 Interaction Pairs May Be Potentially Crucial for Development of Abdominal Aortic Aneurysm by Influencing Inflammation.7

Citation

Dessen P

ACSS2 (acyl-CoA synthetase short chain family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46903/css/js/lib/humanGenome