UBE2R2 (ubiquitin conjugating enzyme E2 R2)

2007-04-01  

Identity

HGNC
UBE2R2
LOCATION
9p13.3
LOCUSID
54926
ALIAS
CDC34B,E2-CDC34B,UBC3B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54926
MIM: 612506
HGNC: 19907
Ensembl: ENSG00000107341

Variants:

dbSNP: 54926
ClinVar: 54926
TCGA: ENSG00000107341
COSMIC: UBE2R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107341ENST00000263228Q712K3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

References

Pubmed IDYearTitleCitations
349420472022Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.9
349420472022Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.9
318685892019Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.28
318685892019Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.28
270448682016Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.11
270448682016Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.11
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.7
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.17
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.7
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.17
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
120376802002CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.17
120376802002CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.17

Citation

Dessen P

UBE2R2 (ubiquitin conjugating enzyme E2 R2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46910/css/img/welcome