ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)

2007-04-01  

Identity

HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
ARI,HARI,HHARI,UBCH7BP
FUSION GENES

Other Information

Locus ID:

NCBI: 25820
MIM: 605624
HGNC: 689
Ensembl: ENSG00000166233

Variants:

dbSNP: 25820
ClinVar: 25820
TCGA: ENSG00000166233
COSMIC: ARIH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166233ENST00000379887Q9Y4X5
ENSG00000166233ENST00000561770H3BUS0
ENSG00000166233ENST00000562891A0A087WT96
ENSG00000166233ENST00000564062H3BNB9
ENSG00000166233ENST00000570085H3BSK4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215325922011UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.192
240766552013TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.38
152369712004Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.36
289306812017Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells.29
296891972018Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.17
230593692013Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.12
285525752017Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.12
287903092017Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.11
215902702012The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies.10
240584162013Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.8

Citation

Dessen P

ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46930/arih1-(ariadne-rbr-e3-ubiquitin-protein-ligase-1)