Identity
HGNC
LOCATION
Xp22.12
LOCUSID
ALIAS
PDHA,PDHAD,PDHCE1A,PHE1A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5160
MIM: 300502
HGNC: 8806
Ensembl: ENSG00000131828
Variants:
dbSNP: 5160
ClinVar: 5160
TCGA: ENSG00000131828
COSMIC: PDHA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37479690 | 2023 | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | 12 |
| 37479690 | 2023 | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | 12 |
| 35132535 | 2022 | Pyruvate Dehydrogenase Complex Deficiency Due to PDHA1 Mutation-A Rare Treatable Cause for Episodic Ataxia in Children. | 1 |
| 35315437 | 2022 | MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. | 12 |
| 35731579 | 2022 | T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes. | 3 |
| 35132535 | 2022 | Pyruvate Dehydrogenase Complex Deficiency Due to PDHA1 Mutation-A Rare Treatable Cause for Episodic Ataxia in Children. | 1 |
| 35315437 | 2022 | MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. | 12 |
| 35731579 | 2022 | T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes. | 3 |
| 33592356 | 2021 | Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother. | 2 |
| 34384830 | 2021 | Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes. | 1 |
| 33592356 | 2021 | Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother. | 2 |
| 34384830 | 2021 | Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes. | 1 |
| 33022274 | 2020 | Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. | 78 |
| 33022274 | 2020 | Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. | 78 |
| 29444744 | 2019 | Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma. | 28 |
Citation
Dessen P
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46942/pdha1
