DDX21 (DExD-box helicase 21)

2007-04-01  

Identity

HGNC
DDX21
LOCATION
10q22.1
LOCUSID
9188
ALIAS
GUA,GURDB,RH-II/GU,RH-II/GuA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9188
MIM: 606357
HGNC: 2744
Ensembl: ENSG00000165732

Variants:

dbSNP: 9188
ClinVar: 9188
TCGA: ENSG00000165732
COSMIC: DDX21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165732ENST00000354185Q9NR30
ENSG00000165732ENST00000620315Q9NR30

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
254700602015RNA helicase DDX21 coordinates transcription and ribosomal RNA processing.78
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
284758952017SLERT Regulates DDX21 Rings Associated with Pol I Transcription.34
247215762014Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein.33
287901572017SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.30
145599042003Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production.29
254773912015The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21.26
284724722017Human DDX21 binds and unwinds RNA guanine quadruplexes.20
181802922008c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.19
208737692010Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.18

Citation

Dessen P

DDX21 (DExD-box helicase 21)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46952/ddx21-(dexd-box-helicase-21)