ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide)

2007-04-01  

Identity

HGNC
ADH7
LOCATION
4q23
LOCUSID
131
ALIAS
ADH4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 131
MIM: 600086
HGNC: 256
Ensembl: ENSG00000196344

Variants:

dbSNP: 131
ClinVar: 131
TCGA: ENSG00000196344
COSMIC: ADH7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196344ENST00000209665P40394
ENSG00000196344ENST00000437033A0A0C4DG85
ENSG00000196344ENST00000474027C9JP14
ENSG00000196344ENST00000476959P40394
ENSG00000196344ENST00000482593E9PFG0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fatty acid degradationKEGGko00071
Tyrosine metabolismKEGGko00350
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Fatty acid degradationKEGGhsa00071
Tyrosine metabolismKEGGhsa00350
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093

References

Pubmed IDYearTitleCitations
377121422023An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease.0
377121422023An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease.0
323888012020Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study.0
323888012020Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study.0
302924902019Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model.8
302924902019Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model.8
287315732018Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood ethanol and acetaldehyde concentrations in healthy subjects with a history of moderate alcohol consumption.1
287315732018Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood ethanol and acetaldehyde concentrations in healthy subjects with a history of moderate alcohol consumption.1
245125522014Single-nucleotide polymorphisms interact to affect ADH7 transcription.8
247227352014Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.11
255278932014Protective variant associated with alcohol dependence in a Mexican American cohort.10
245125522014Single-nucleotide polymorphisms interact to affect ADH7 transcription.8
247227352014Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.11
255278932014Protective variant associated with alcohol dependence in a Mexican American cohort.10
234681742013Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.13

Citation

Dessen P

ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46969/adh7-(alcohol-dehydrogenase-7-(class-iv)-mu-or-sigma-polypeptide)