IMPA2 (inositol monophosphatase 2)

2007-04-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3613
MIM: 605922
HGNC: 6051
Ensembl: ENSG00000141401

Variants:

dbSNP: 3613
ClinVar: 3613
TCGA: ENSG00000141401
COSMIC: IMPA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141401ENST00000269159O14732
ENSG00000141401ENST00000383376Q6PIP6
ENSG00000141401ENST00000586230K7EIH6
ENSG00000141401ENST00000588927K7EII9
ENSG00000141401ENST00000589238K7EII9
ENSG00000141401ENST00000590107K7ELF8
ENSG00000141401ENST00000590138K7EL65
ENSG00000141401ENST00000625802Q6PIP6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGhsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGM00131
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP2, IP, and Ins in the cytosolREACTOMER-HSA-1855183

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380488422024IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop.0
380488422024IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop.0
324096482020A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.8
324096482020A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.8
312028132019Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma.14
312028132019Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma.14
294995052018Association between genetic variation in the myo-inositol monophosphatase 2 (IMPA2) gene and age at onset of bipolar disorder.5
294995052018Association between genetic variation in the myo-inositol monophosphatase 2 (IMPA2) gene and age at onset of bipolar disorder.5
277485502017A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.3
277485502017A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.3
276611092016IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population.3
276611092016IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population.3
234536402013Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.14
234536402013Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.14
212130022011In silico study on the substrate binding manner in human myo-inositol monophosphatase 2.2

Citation

Dessen P

IMPA2 (inositol monophosphatase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46987/impa2-(inositol-monophosphatase-2)