Identity
HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
PLC-delta-3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 113026
MIM: 608795
HGNC: 9061
Ensembl: ENSG00000161714
Variants:
dbSNP: 113026
ClinVar: 113026
TCGA: ENSG00000161714
COSMIC: PLCD3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000161714 | ENST00000538093 | F5GXC1 |
| ENSG00000161714 | ENST00000539433 | H0YGF8 |
| ENSG00000161714 | ENST00000590644 | K7EQF2 |
| ENSG00000161714 | ENST00000619929 | Q8N3E9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA26097 | CASR | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA33767 | PRKCH | Gene | Pathway | associated | |||
| PA33768 | PRKCI | Gene | Pathway | associated | |||
| PA33771 | PRKD1 | Gene | Pathway | associated | |||
| PA33775 | PRKCZ | Gene | Pathway | associated | |||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 22525200 | |
| PA449334 | diltiazem | Chemical | ClinicalAnnotation | associated | PD | 22525200 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36071682 | 2023 | CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract. | 0 |
| 37166441 | 2023 | Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression. | 2 |
| 37773107 | 2023 | PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling. | 0 |
| 36071682 | 2023 | CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract. | 0 |
| 37166441 | 2023 | Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression. | 2 |
| 37773107 | 2023 | PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling. | 0 |
| 33674820 | 2021 | Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway. | 8 |
| 33674820 | 2021 | Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway. | 8 |
| 31808619 | 2020 | Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms. | 7 |
| 31808619 | 2020 | Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms. | 7 |
| 29115528 | 2018 | PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells. | 15 |
| 29115528 | 2018 | PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells. | 15 |
| 23948486 | 2013 | Physiological functions of phospholipase Cδ1 and phospholipase Cδ3. | 9 |
| 23948486 | 2013 | Physiological functions of phospholipase Cδ1 and phospholipase Cδ3. | 9 |
| 22723964 | 2012 | Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant. | 5 |
Citation
Dessen P
PLCD3 (phospholipase C delta 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47013/plcd3-(phospholipase-c-delta-3)
