RGS6 (regulator of G protein signaling 6)

2007-04-01  

Identity

HGNC
RGS6
LOCATION
14q24.2
LOCUSID
9628
ALIAS
GAP,HA117,S914
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9628
MIM: 603894
HGNC: 10002
Ensembl: ENSG00000182732

Variants:

dbSNP: 9628
ClinVar: 9628
TCGA: ENSG00000182732
COSMIC: RGS6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182732ENST00000343854A0A0A0MRA9
ENSG00000182732ENST00000355512P49758
ENSG00000182732ENST00000402788B7Z2N1
ENSG00000182732ENST00000404301P49758
ENSG00000182732ENST00000406236P49758
ENSG00000182732ENST00000407322P49758
ENSG00000182732ENST00000434263B7Z7N5
ENSG00000182732ENST00000553525P49758
ENSG00000182732ENST00000553530P49758
ENSG00000182732ENST00000553530Q2M3K2
ENSG00000182732ENST00000554474P49758
ENSG00000182732ENST00000554782P49758
ENSG00000182732ENST00000555571P49758
ENSG00000182732ENST00000555571Q2M3K2
ENSG00000182732ENST00000556437P49758
ENSG00000182732ENST00000622468A0A087WTW9
ENSG00000182732ENST00000644463A0A2R8Y8A2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
384091362024RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.0
384091362024RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.0
359025572022RGS6 suppresses TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4.8
359025572022RGS6 suppresses TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4.8
311204392019Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.11
311204392019Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.11
280900392017Interaction between the RGS6 gene and psychosocial stress on obesity-related traits.2
286659812017HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6.3
287310262017The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells.0
280900392017Interaction between the RGS6 gene and psychosocial stress on obesity-related traits.2
286659812017HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6.3
287310262017The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells.0
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.5
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.5
263404332015A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.9

Citation

Dessen P

RGS6 (regulator of G protein signaling 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47027/rgs6-(regulator-of-g-protein-signaling-6)