METTL4 (methyltransferase 4, N6-adenosine)

2007-04-01  

Identity

HGNC
METTL4
LOCATION
18p11.32
LOCUSID
64863
ALIAS
HsT661
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64863
HGNC: 24726
Ensembl: ENSG00000101574

Variants:

dbSNP: 64863
ClinVar: 64863
TCGA: ENSG00000101574
COSMIC: METTL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101574ENST00000319888J3KNJ7
ENSG00000101574ENST00000574538Q8N3J2
ENSG00000101574ENST00000574676I3L4A0
ENSG00000101574ENST00000576251I3L3W2
ENSG00000101574ENST00000577166I3L0Y1
ENSG00000101574ENST00000609769V9GYU3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351629822022N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4.13
351629822022N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4.13
319133602020METTL4 is an snRNA m(6)Am methyltransferase that regulates RNA splicing.67
321839422020N(6)-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.97
328130092020METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.42
328130092020METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.42
319133602020METTL4 is an snRNA m(6)Am methyltransferase that regulates RNA splicing.67
321839422020N(6)-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.97
328130092020METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.42
328130092020METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.42
273733372016Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.560
273733372016Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.560
238349542013Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.5
238349542013Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.5

Citation

Dessen P

METTL4 (methyltransferase 4, N6-adenosine)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47028/mettl4-(methyltransferase-4-n6-adenosine)