PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma)

2007-04-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
PIP5K2C
FUSION GENES

Other Information

Locus ID:

NCBI: 79837
MIM: 617104
HGNC: 23786
Ensembl: ENSG00000166908

Variants:

dbSNP: 79837
ClinVar: 79837
TCGA: ENSG00000166908
COSMIC: PIP4K2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166908ENST00000354947Q8TBX8
ENSG00000166908ENST00000422156Q8TBX8
ENSG00000166908ENST00000540759Q8TBX8
ENSG00000166908ENST00000548264H0YIJ6
ENSG00000166908ENST00000550095F8VU68
ENSG00000166908ENST00000550360F8VVB2
ENSG00000166908ENST00000550465Q8TBX8
ENSG00000166908ENST00000551772F8VNT5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Regulation of actin cytoskeletonKEGGko04810
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
PI5P Regulates TP53 AcetylationREACTOMER-HSA-6811555
Synthesis of PIPs in the nucleusREACTOMER-HSA-8847453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187948532008Common variants at CD40 and other loci confer risk of rheumatoid arthritis.199
196448592009Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.28
204392922010Genetic variants in the prediction of rheumatoid arthritis.12
310914392019PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.2
311095952019PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.0

Citation

Dessen P

PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47050/pip4k2c-(phosphatidylinositol-5-phosphate-4-kinase-type-2-gamma)