Identity
HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
E4,UBOX2,UFD2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9354
MIM: 603753
HGNC: 12499
Ensembl: ENSG00000110344
Variants:
dbSNP: 9354
ClinVar: 9354
TCGA: ENSG00000110344
COSMIC: UBE4A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000110344 | ENST00000252108 | Q14139 |
| ENSG00000110344 | ENST00000431736 | Q14139 |
| ENSG00000110344 | ENST00000545354 | B7Z7P0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37084817 | 2023 | UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. | 1 |
| 37084817 | 2023 | UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. | 1 |
| 35136024 | 2022 | PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability. | 8 |
| 35136024 | 2022 | PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability. | 8 |
| 33420346 | 2021 | Biallelic UBE4A loss-of-function variants cause intellectual disability and global developmental delay. | 1 |
| 33420346 | 2021 | Biallelic UBE4A loss-of-function variants cause intellectual disability and global developmental delay. | 1 |
| 29499138 | 2018 | The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. | 29 |
| 29499138 | 2018 | The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. | 29 |
| 27862841 | 2017 | The ubiquitin ligase UBE4A inhibits prostate cancer progression by targeting interleukin-like EMT inducer (ILEI). | 10 |
| 28963376 | 2017 | Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. | 6 |
| 27862841 | 2017 | The ubiquitin ligase UBE4A inhibits prostate cancer progression by targeting interleukin-like EMT inducer (ILEI). | 10 |
| 28963376 | 2017 | Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. | 6 |
| 18069675 | 2008 | Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. | 15 |
| 18069675 | 2008 | Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. | 15 |
| 17553343 | 2007 | [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. | 7 |
Citation
Dessen P
UBE4A (ubiquitination factor E4A)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47051/ube4a-(ubiquitination-factor-e4a)
