DUOXA1 (dual oxidase maturation factor 1)

2007-04-01  

Identity

HGNC
DUOXA1
LOCATION
15q21.1
LOCUSID
90527
ALIAS
NIP,NUMBIP,mol

Other Information

Locus ID:

NCBI: 90527
MIM: 612771
HGNC: 26507
Ensembl: ENSG00000140254

Variants:

dbSNP: 90527
ClinVar: 90527
TCGA: ENSG00000140254
COSMIC: DUOXA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140254ENST00000267803Q1HG43
ENSG00000140254ENST00000267803A8K9Q6
ENSG00000140254ENST00000430224B5M0C0
ENSG00000140254ENST00000558326H0YNR1
ENSG00000140254ENST00000558377H0YLQ4
ENSG00000140254ENST00000558422Q1HG43
ENSG00000140254ENST00000558422B5M0B8
ENSG00000140254ENST00000558851H0YLI1
ENSG00000140254ENST00000558996Q1HG43
ENSG00000140254ENST00000558996B5M0B8
ENSG00000140254ENST00000559013H0YMH9
ENSG00000140254ENST00000559014Q1HG43
ENSG00000140254ENST00000559014A8K9Q6
ENSG00000140254ENST00000559226H0YKF3
ENSG00000140254ENST00000559644H0YKG3
ENSG00000140254ENST00000559988H0YMZ8
ENSG00000140254ENST00000560572Q1HG43
ENSG00000140254ENST00000560572B5M0B7
ENSG00000140254ENST00000613425B5M0C0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334200712021Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.21
334200712021Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.21
297045172018DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.38
297045172018DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.38
272629812016Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.12
272629812016Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.12
193226542010NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics.11
193226542010NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics.11
193395562009Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.37
193395562009Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.37

Citation

Dessen P

DUOXA1 (dual oxidase maturation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47065/duoxa1-(dual-oxidase-maturation-factor-1)