CAB39 (calcium binding protein 39)

2007-04-01 Affiliation

Identity

HGNC

CAB39

LOCATION

2q37.1

LOCUSID

51719

ALIAS

CGI-66,MO25

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51719
MIM: 612174
HGNC: 20292
Ensembl: ENSG00000135932

Variants:

dbSNP: 51719
ClinVar: 51719
TCGA: ENSG00000135932
COSMIC: CAB39

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135932	ENST00000258418	Q9Y376
ENSG00000135932	ENST00000258418	A0A024R496
ENSG00000135932	ENST00000409788	Q9Y376
ENSG00000135932	ENST00000409788	A0A024R496
ENSG00000135932	ENST00000410084	Q9Y376
ENSG00000135932	ENST00000410084	A0A024R496
ENSG00000135932	ENST00000614925	A0A087X0K1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
mTOR signaling pathway	KEGG	hsa04150
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19892943	2009	Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.	102
19386264	2009	Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.	74
19513107	2009	ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.	54
21423148	2011	MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.	51
22179124	2012	MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma.	43
18854318	2009	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	29
28605041	2017	Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.	16
28197410	2017	MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39.	10
30779944	2019	MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.	9
23296203	2013	Structural insights into the activation of MST3 by MO25.	7

Citation

Dessen P

CAB39 (calcium binding protein 39)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47073/cab39-(calcium-binding-protein-39)