LDHC (lactate dehydrogenase C)

2007-04-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
CT32,LDH3,LDHX
FUSION GENES

Other Information

Locus ID:

NCBI: 3948
MIM: 150150
HGNC: 6544
Ensembl: ENSG00000166796

Variants:

dbSNP: 3948
ClinVar: 3948
TCGA: ENSG00000166796
COSMIC: LDHC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166796ENST00000280704P07864
ENSG00000166796ENST00000280704A0A140VKA7
ENSG00000166796ENST00000396215F5H326
ENSG00000166796ENST00000535809F5H155
ENSG00000166796ENST00000536880F5H245
ENSG00000166796ENST00000537486F5GZ11
ENSG00000166796ENST00000539369F5GWS6
ENSG00000166796ENST00000541669P07864
ENSG00000166796ENST00000541669A0A140VKA7
ENSG00000166796ENST00000544105G3XAP5
ENSG00000166796ENST00000545848F5H326
ENSG00000166796ENST00000546146F5H5G7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340506112022Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy.9
340506112022Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy.9
347088882021Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.8
347088882021Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.8
317947642020Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer.28
317947642020Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer.28
292249232018Allele-specific methylation of type 1 diabetes susceptibility genes.14
292249232018Allele-specific methylation of type 1 diabetes susceptibility genes.14
283513042017Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma.21
283513042017Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma.21
257956312015Quick histochemical staining method for measuring lactate dehydrogenase C4 activity in human spermatozoa.1
260693372015Lactate dehydrogenase isoenzyme 3 and hemolysis in sickle cell anemia: a possible correlation?2
265035492015Differences in urinary proteins related to surgical margin status after radical prostatectomy.6
257956312015Quick histochemical staining method for measuring lactate dehydrogenase C4 activity in human spermatozoa.1
260693372015Lactate dehydrogenase isoenzyme 3 and hemolysis in sickle cell anemia: a possible correlation?2

Citation

Dessen P

LDHC (lactate dehydrogenase C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47075/ldhc-(lactate-dehydrogenase-c)