ADAM2 (ADAM metallopeptidase domain 2)

2007-04-01  

Identity

HGNC
ADAM2
LOCATION
8p11.22
LOCUSID
2515
ALIAS
CRYN1,CRYN2,CT15,FTNB,PH-30b,PH30,PH30-beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2515
MIM: 601533
HGNC: 198
Ensembl: ENSG00000104755

Variants:

dbSNP: 2515
ClinVar: 2515
TCGA: ENSG00000104755
COSMIC: ADAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104755ENST00000265708Q99965
ENSG00000104755ENST00000347580Q99965
ENSG00000104755ENST00000379853Q6P2G0
ENSG00000104755ENST00000521880B4DWY7
ENSG00000104755ENST00000622267B4DWY7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Interaction With The Zona PellucidaREACTOMER-HSA-1300644

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359332932022Is there a relationship between infertility and fertilin β protein distribution?1
359332932022Is there a relationship between infertility and fertilin β protein distribution?1
304634552020Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection.2
304634552020Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection.2
262524782015Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.6
262524782015Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.6
182928402007Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.13
182928402007Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.13

Citation

Dessen P

ADAM2 (ADAM metallopeptidase domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47076/adam2-(adam-metallopeptidase-domain-2)