ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3)

2007-04-01  

Identity

HGNC
ADAMTS3
LOCATION
4q13.3
LOCUSID
9508
ALIAS
ADAMTS-4,HKLLS3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9508
MIM: 605011
HGNC: 219
Ensembl: ENSG00000156140

Variants:

dbSNP: 9508
ClinVar: 9508
TCGA: ENSG00000156140
COSMIC: ADAMTS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156140ENST00000286657O15072
ENSG00000156140ENST00000622135O15072

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
373362682023ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation.5
373362682023ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation.5
287964142018Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.3
295185492018SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models.10
304507632018An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3.5
287964142018Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.3
295185492018SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models.10
304507632018An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3.5
280882712017ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.4
289853532017Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.40
280882712017ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.4
289853532017Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.40
258631612015The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.54
258631612015The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.54
222051752012Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.9

Citation

Dessen P

ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47092/adamts3-(adam-metallopeptidase-with-thrombospondin-type-1-motif-3)