RNF41 (ring finger protein 41)

2007-04-01 Affiliation

Identity

HGNC

RNF41

LOCATION

12q13.3

LOCUSID

10193

ALIAS

FLRF,NRDP1,SBBI03

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10193
HGNC: 18401
Ensembl: ENSG00000181852

Variants:

dbSNP: 10193
ClinVar: 10193
TCGA: ENSG00000181852
COSMIC: RNF41

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181852	ENST00000345093	Q9H4P4
ENSG00000181852	ENST00000345093	A0A024RB33
ENSG00000181852	ENST00000394013	Q9H4P4
ENSG00000181852	ENST00000547967	F8VVY2
ENSG00000181852	ENST00000549038	F8VSP7
ENSG00000181852	ENST00000549119	F8VSE5
ENSG00000181852	ENST00000551711	F8VNZ6
ENSG00000181852	ENST00000552244	F8VSB6
ENSG00000181852	ENST00000552656	Q9H4P4
ENSG00000181852	ENST00000552656	A0A024RB33
ENSG00000181852	ENST00000615206	Q9H4P4
ENSG00000181852	ENST00000615206	A0A024RB33

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Signal Transduction	REACTOME	R-HSA-162582
Signaling by ERBB2	REACTOME	R-HSA-1227986
Downregulation of ERBB2:ERBB3 signaling	REACTOME	R-HSA-1358803
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17035239	2006	Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).	66
15314180	2004	Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.	62
17210635	2007	Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.	54
14765125	2004	Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.	45
21576364	2011	Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum.	27
20587519	2010	Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells.	22
21378310	2011	RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding.	22
23750007	2013	Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.	18
20628057	2010	Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors.	11
24259665	2014	Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity.	10

Citation

Dessen P

RNF41 (ring finger protein 41)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47099/rnf41-(ring-finger-protein-41)